DIFFERENTIAL-EFFECTS OF BASOLATERAL AMYGDALA LESIONS ON BEHAVIOR, CORTICOSTERONE, AND PROLACTIN RESPONSES

被引:9
作者
SEGGIE, J
机构
[1] Jo Seggie, Ph.D., is an Ontario Mental Health Foundation Research Associate
[2] Dr. Seggie is also Associate Professor, Departments of Neurosciences and Psychiatry, McMaster University
关键词
Amygdala; behavior; corticosterone; prolactin; stress;
D O I
10.1016/0165-1781(79)90010-6
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The present experiment examines hormone-behavior relationships following manipulation of the amygdala. Affective behavior and levels of corticosterone and prolactin were compared in rats with lesions of the basolateral amygdala and in nonlesioned and sham-operated controls. Animals with lesions of the basolateral amygdala were found to be hyperreactive and to have normal resting levels of corticosterone and prolactin but potentiated corticosterone responses to stress. Normal prolactin stress responses were unaltered by the lesion. The results are discussed in relation to behavioral and endocrine changes seen following other limbic system lesions. © 1979.
引用
收藏
页码:283 / 295
页数:13
相关论文
共 42 条
[31]   Differential effects of increased corticosterone on behavior at the nest and reproductive output of chick-rearing Adélie penguins [J].
Anne-Mathilde Thierry ;
Sophie Brajon ;
Marion Spée ;
Thierry Raclot .
Behavioral Ecology and Sociobiology, 2014, 68 :721-732
[32]   Differential effects of increased corticosterone on behavior at the nest and reproductive output of chick-rearing Ad,lie penguins [J].
Thierry, Anne-Mathilde ;
Brajon, Sophie ;
Spee, Marion ;
Raclot, Thierry .
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY, 2014, 68 (05) :721-732
[33]   The effects of acute and chronic administration of corticosterone on rat behavior in two models of fear responses, plasma corticosterone concentration, and c-Fos expression in the brain structures [J].
Skorzewska, Anna ;
Bidzinski, Andrzej ;
Lehner, Malgorzata ;
Turzynska, Danuta ;
Wislowska-Stanek, Aleksandra ;
Sobolewska, Alicja ;
Szyndler, Janusz ;
Maciejak, Piotr ;
Taracha, Ewa ;
Plaznik, Adam .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2006, 85 (03) :522-534
[34]   LOCAL REPEATED CORTICOTROPIN-RELEASING FACTOR INFUSION EXACERBATES ANXIETY- AND FEAR-RELATED BEHAVIOR: DIFFERENTIAL INVOLVEMENT OF THE BASOLATERAL AMYGDALA AND MEDIAL PREFRONTAL CORTEX [J].
Bijlsma, E. Y. ;
van Leeuwen, M. L. F. ;
Westphal, K. G. C. ;
Olivier, B. ;
Groenink, L. .
NEUROSCIENCE, 2011, 173 :82-92
[35]   Effects of treadmill exercise and chronic stress on anxiety-like behavior, neuronal activity, and oxidative stress in basolateral amygdala in morphine-treated rats [J].
Shahidani, Somayeh ;
Jokar, Zahra ;
Alaei, Hojjatallah ;
Reisi, Parham .
SYNAPSE-STRUCTURE FUNCTION CONNECTIVITY, 2023, 77 (01)
[36]   Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and place conditioning based on path integration in a novel Y-maze procedure [J].
Ito, Rutsuko ;
Robbins, Trevor W. ;
McNaughton, Bruce L. ;
Everitt, Barry J. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2006, 23 (11) :3071-3080
[37]   DOPAMINERGIC ANTAGONISM WITHIN THE NUCLEUS-ACCUMBENS OR THE AMYGDALA PRODUCES DIFFERENTIAL-EFFECTS ON INTRAVENOUS COCAINE SELF-ADMINISTRATION UNDER FIXED AND PROGRESSIVE RATIO SCHEDULES OF REINFORCEMENT [J].
MCGREGOR, A ;
ROBERTS, DCS .
BRAIN RESEARCH, 1993, 624 (1-2) :245-252
[38]   Fluoxetine and environmental enrichment similarly reverse chronic social stress-related depression- and anxiety-like behavior, but have differential effects on amygdala gene expression [J].
Cordner, Zachary A. ;
Marshall-Thomas, Isaiah ;
Boersma, Gretha J. ;
Lee, Richard S. ;
Potash, James B. ;
Tamashiro, Kellie L. K. .
NEUROBIOLOGY OF STRESS, 2021, 15
[39]   Sex- and age-dependent effects of chronic corticosterone exposure on depressive-like, anxiety-like, and fear-related behavior: Role of amygdala glutamate receptors in the rat [J].
Bertholomey, Megan L. ;
Nagarajan, Vidhya ;
Smith, Dana M. ;
Torregrossa, Mary M. .
FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2022, 16
[40]   Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats [J].
Nguyen, Elizabeth T. ;
Caldwell, Jody L. ;
Streicher, Joshua ;
Ghisays, Valentina ;
Balmer, Nikolaus J. ;
Estrada, Christina M. ;
Solomon, Matia B. .
BEHAVIOURAL BRAIN RESEARCH, 2018, 336 :99-110