DEVELOPMENT OF T-CELL LEUKEMIA IN AN ATAXIA TELANGIECTASIA PATIENT FOLLOWING CLONAL SELECTION IN T(X-14)-CONTAINING LYMPHOCYTES

被引：0

作者：

TAYLOR, AMR ^{[1
]}

LOWE, PA ^{[1
]}

STACEY, M ^{[1
]}

THICK, J ^{[1
]}

CAMPBELL, L ^{[1
]}

BEATTY, D ^{[1
]}

BIGGS, P ^{[1
]}

FORMSTONE, CJ ^{[1
]}

机构：

[1] UNIV CAPE TOWN, RED CROSS WAR MEM CHILDRENS HOSP, DEPT PAEDIAT & CHILD HLTH, RONDEBOSCH 7700, SOUTH AFRICA

来源：

LEUKEMIA | 1992年 / 6卷 / 09期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ataxia telangiectasia is a rare inherited and progressive neurological disorder in which patients show an unusual predisposition to T-cell leukaemia. We report here observations on a patient with a large cytogenetically abnormal clone showing a single t(X;14)(q28;q11) translocation which conferred a proliferative advantage on the cells. The further evolution of this clone to cytogenetically more complex clones of lymphocytes was seen in the patient. She subsequently developed a rapidly progressing T-cell leukaemia, with a CD4+CD8+T-cell phenotype, about five years after the first appearance of additional chromosome translocation in the clone cells.

引用

页码：961 / 966

页数：6

共 27 条

[1] THE BREAKPOINT OF AN INVERSION OF CHROMOSOME-14 IN A T-CELL LEUKEMIA - SEQUENCES DOWNSTREAM OF THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS ARE IMPLICATED IN TUMORIGENESIS [J].