KILLING OF PLASMODIUM-FALCIPARUM INVITRO BY NITRIC-OXIDE DERIVATIVES

被引：286

作者：

ROCKETT, KA ^{[1
]}

AWBURN, MM ^{[1
]}

COWDEN, WB ^{[1
]}

CLARK, IA ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV, DIV BIOCHEM & MOLEC BIOL, CANBERRA, ACT 2601, AUSTRALIA

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 09期

关键词：

D O I：

10.1128/IAI.59.9.3280-3283.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not inhibit parasite growth, but two oxidation products of nitric oxide (nitrite and nitrate ions) were toxic to the parasite in millimolar concentrations. Nitrosothiol derivatives of cysteine and glutathione were found to be about a thousand times more active (50% growth inhibitory concentration, approximately 40-mu-M) than nitrite.

引用

页码：3280 / 3283

页数：4

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