VACUUM LIQUID-CHROMATOGRAPHY - ALTERNATIVE TO COMMON CHROMATOGRAPHIC METHODS

被引:89
作者
TARGETT, NM
KILCOYNE, JP
GREEN, B
机构
[1] UNIV MAINE,DEPT CHEM,ORONO,ME 04469
[2] UNIV MAINE,DEPT OCEANOG,ORONO,ME 04469
关键词
D O I
10.1021/jo00394a045
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
There is a constant need in organic chemistry to separate both large and small quantities of mixtures efficiently, rapidly, and inexpensively. Unfortunately, it is seldom that all three of these requirements are satisfied in the commonly used chromatographic techniques. Efforts to improve these methods include the use of multibore columns, 1 flash chromatography, 2 automated systems, 3 and drycolumn chromatography. 4 We wish to report the development of vacuum liquid chromatography (VLC), a method which we feel possesses all of the desirable characteristics mentioned above. VLC has become the major method for separation of steroids and marine natural products in our laboratory. © 1979, American Chemical Society. All rights reserved.
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页码:4962 / 4964
页数:3
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