NEOPLASTIC TRANSFORMATION AND DOSE FRACTIONATION - DOES REPAIR OF DAMAGE PLAY A ROLE

被引：20
作者：
ELKIND, MM
HAN, A
机构：
来源：
RADIATION RESEARCH | 1979年 / 79卷 / 02期
关键词：
D O I：
10.2307/3575094
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The induction of neoplastically transformed cells has been measured with single and fractionated doses of 50-kV X rays and fission-spectrum neutrons from the JANUS reactor at the Argonne National Laboratory. Combining these results with parallel measurements of cell survival permits an analysis of the possible roles of repair processes in the expression of sublethal and subtransformation damage. It is concluded that subtransformation damage due to X rays is repaired although probably more slowly than sublethal X-ray damage. Much less, if any, repair occurs between neutron doses for periods up to 24 hr.
引用
收藏
页码：233 / 240
页数：8
相关论文
共 12 条
[1]   EFFECT OF SPLIT DOSES OF X-RAYS ON NEOPLASTIC TRANSFORMATION OF SINGLE CELLS [J].
BOREK, C ;
HALL, EJ .
NATURE, 1974, 252 (5483) :499-501
[2]   IN VITRO CELL TRANSFORMATION BY X-IRRADIATION [J].
BOREK, C ;
SACHS, L .
NATURE, 1966, 210 (5033) :276-&
[3]   TRANSFORMATION OF MAMMALIAN-CELLS IN-VITRO BY LOW DOSES OF X-RAYS [J].
BOREK, C ;
HALL, EJ .
NATURE, 1973, 244 (5408) :450-453
[4]   X-RAY DAMAGE AND RECOVERY IN MAMMALIAN CELLS IN CULTURE [J].
ELKIND, MM ;
SUTTON, H .
NATURE, 1959, 184 (4695) :1293-1295
[5]   RADIATION RESPONSE OF MAMMALIAN CELLS GROWN IN CULTURE .1. REPAIR OF X-RAY DAMAGE IN SURVIVING CHINESE HAMSTER CELLS [J].
ELKIND, MM ;
SUTTON, H .
RADIATION RESEARCH, 1960, 13 (04) :556-593
[6]  
Gray LH, 1965, CELLULAR RAD BIOL, P7
[7]  
HAN A, 1979, CANCER RES, V39, P123
[8]   X-RAY DOSE FRACTIONATION AND ONCOGENIC TRANSFORMATIONS IN CULTURED MOUSE EMBRYO CELLS [J].
MILLER, R ;
HALL, EJ .
NATURE, 1978, 272 (5648) :58-60
[9]   COMPARATIVE RADIOBIOLOGY OF FAST-NEUTRONS - RELEVANCE TO RADIOTHERAPY AND BASIC STUDIES [J].
NGO, FQH ;
HAN, A ;
UTSUMI, H ;
ELKIND, MM .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1977, 3 :187-193
[10]  
NGO FQH, INT J RAD BIOL
12