LINGUISTIC FEATURES OF NONCODING DNA-SEQUENCES

被引：232

作者：

MANTEGNA, RN

BULDYREV, SV

GOLDBERGER, AL

HAVLIN, S

PENG, CK

SIMONS, M

STANLEY, HE

机构：

[1] BOSTON UNIV, DEPT PHYS, BOSTON, MA 02215 USA

[2] HARVARD UNIV, BETH ISRAEL HOSP, SCH MED, DIV CARDIOVASC, BOSTON, MA 02215 USA

来源：

PHYSICAL REVIEW LETTERS | 1994年 / 73卷 / 23期

关键词：

D O I：

10.1103/PhysRevLett.73.3169

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We extend the Zipf approach to analyzing linguistic texts to the statistical study of DNA base pair sequences and find that the noncoding regions are more similar to natural languages than the coding regions. We also adapt the Shannon approach to quantifying the "redundancy" of a linguistic text in terms of a measurable entropy function, and demonstrate that noncoding regions in eukaryotes display a smaller entropy and larger redundancy than coding regions, supporting the possibility that noncoding regions of DNA may carry biological information. © 1994 The American Physical Society.

引用

页码：3169 / 3172

页数：4

共 20 条

[1] NUCLEOTIDE DISTRIBUTION AND THE RECOGNITION OF CODING REGIONS IN DNA-SEQUENCES - AN INFORMATION-THEORY APPROACH [J].