DETERMINATION OF FLUOROQUINOLONE ANTIBACTERIALS AS N-ACYL DERIVATIVES

被引：10
|
作者：
MORLEY, JA
ELROD, L
机构：
[1] Physical Analytical Chemistry Department, Abbott Laboratories, North Chicago, 60064-4000, Illinois
来源：
CHROMATOGRAPHIA | 1993年 / 37卷 / 5-6期
关键词：
COLUMN LIQUID CHROMATOGRAPHY; FLUOROQUINOLONES; N-ACYL DERIVATIVES OF FLUOROQUINOLONES; RETENTION VS STRUCTURE;
D O I：
10.1007/BF02278637
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple and quantitative method for the preparation and high performance liquid chromatography (HPLC) of N-acylated fluoroquinolones has been developed. The acylation procedure was performed with four different acid anhydrides and found to be applicable to several fluoroquinolones. The acylated derivatives were chromatographed directly on a Nucleosil C18 column without the necessity of further sample manipulation. Detector response for the N-acetyl derivatives of norfloxacin, ciprofloxacin, sarafloxacin, and temafloxacin was linear to at least 50 mug/mL. The retention behavior of the N-acyl derivatives can be predicted by the length of the carbon chain of the amide.
引用
收藏
页码：295 / 299
页数：5
相关论文
共 50 条
  • [31] Synthesis of osteotropic hydroxybisphosphonate derivatives of fluoroquinolone antibacterials
    McPherson, James C., III
    Runner, Royce
    Buxton, Thomas B.
    Hartmann, John F.
    Farcasiu, Dan
    Bereczki, Ilona
    Roth, Erzsebet
    Tollas, Szilvia
    Ostorhazi, Eszter
    Rozgonyi, Ferenc
    Herczegh, Pal
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 47 : 615 - 618
  • [32] IRRITANT ACTION OF N-ACYL DERIVATIVES OF GLUTAMIC AND ASPARTIC ACIDS
    GARYAYEV, AP
    KONONOV, OV
    DUMPIS, MA
    PIOTROVSKY, LB
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1990, 24 (05): : 20 - 22
  • [33] SYNTHESIS AND PROPERTIES OF SOME N-ACYL DERIVATIVES OF CARMINOMYCIN AND RUBOMYCIN
    OLSUFYEVA, EN
    POVAROV, LS
    ANTIBIOTIKI, 1980, 25 (05): : 333 - 338
  • [34] CHIRAL DISCRIMINATION IN N-ACYL AMINO-ACID DERIVATIVES
    STINE, KJ
    UANG, JYJ
    PARAZAK, DP
    DINGMAN, SD
    WHITT, SA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 206 : 155 - COLL
  • [35] Nonlinear optical and antimicrobial activity of N-acyl glycine derivatives
    Nourai, Nour El Houda
    Sebih, Fatiha
    Hadji, Djebar
    Allal, Fatima Zohra
    Dib, Soulef
    Kambouche, Nadia
    Rolland, Valerie
    Bellahouel-Benzine, Salima
    JOURNAL OF MOLECULAR LIQUIDS, 2024, 398
  • [36] Study on foaming properties of N-acyl amino acid surfactants: Sodium N-acyl glycinate and sodium N-acyl phenylalaninate
    Zhao, Huanxia
    He, Chengxuan
    Zhou, Yawen
    Yang, Jian
    Luo, Cong
    Xu, Baocai
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2019, 567 : 240 - 248
  • [37] N-Acyl Derivatives of 4-Phenoxyaniline as Neuroprotective Agents
    Barho, Marlene T.
    Oppermann, Sina
    Schrader, Florian C.
    Degenhardt, Inga
    Elsaesser, Katharina
    Wegscheid-Gerlach, Christof
    Culmsee, Carsten
    Schlitzer, Martin
    CHEMMEDCHEM, 2014, 9 (10) : 2260 - 2273
  • [38] Synthesis and Cytotoxicity of O- and N-Acyl Derivatives of Azepanobetulin
    Lopatina, T. V.
    Medvedeva, N. I.
    Baikova, I. P.
    Iskhakov, A. S.
    Kazakova, O. B.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2019, 45 (04) : 292 - 301
  • [39] SYNTHESIS AND STRUCTURED N-ACYL AND THIOUREA DERIVATIVES CITIZINE AND ANABAZINE
    Nurkenov, O. A.
    Nurmaganbetov, Zh S.
    Seilkhanov, T. M.
    Fazylov, S. D.
    Manasheva, V. M.
    Zhasymbekova, A. R.
    Serikbolov, A. S.
    NEWS OF THE NATIONAL ACADEMY OF SCIENCES OF THE REPUBLIC OF KAZAKHSTAN-SERIES CHEMISTRY AND TECHNOLOGY, 2020, (01): : 37 - 46
  • [40] SYNTHESIS AND SPECTRAL PROPERTIES OF SOME N-ACYL HYDRASTININE DERIVATIVES
    ROZWADOWSKA, MD
    POLISH JOURNAL OF CHEMISTRY, 1978, 52 (04) : 823 - 829
12345