REGIONAL DIFFERENCES FOR THE D-AMINO-ACID OXIDASE-CATALYZED OXIDATION OF D-METHIONINE IN CHICKEN SMALL-INTESTINE

被引：22

作者：

BRACHET, P ^{[1
]}

PUIGSERVER, A ^{[1
]}

机构：

[1] CNRS,CTR BIOCHIM & BIOL MOLEC,F-13402 MARSEILLE 9,FRANCE

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1992年 / 101卷 / 04期

关键词：

D O I：

10.1016/0305-0491(92)90329-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Enzymic oxidation of D-[1-C-14]methionine (D-met) to 2-keto-4-methylthiobutanoate (KMB) has been determined using 100,000 g supernatants prepared from chicken tissue homogenates. 2. The small intestinal mucosa contains substantial oxidative activity towards D-met, which represents about one-half and one-tenth the hepatic and renal activity, respectively. 3. KMB is poorly decarboxylated and rather transaminated to L-met. 4. The specific activity for D-met oxidation in the duodenal mucosa is 1.5- and 4.0-fold that in the jejunal and ileal mucosa, respectively. 5. The intestinal D-met-oxidizing activity is dramatically altered by the D-amino acid oxidase specific inhibitor benzoate.

引用

页码：509 / 511

页数：3

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