Heparin-induced thrombocytopenia (HIT) type II is caused by an immune response involving antibody formation to the heparin-platelet factor 4 complex. An activation of platelets leads to an uncontrolled generation of thrombin which in turn leads to arterial and/or venous thrombosis. Untreated this condition can result in loss of limbs or fulminant pulmonary embolism. As the main trigger is the administration of unfractionated heparin it is paramount to immediately stop heparinization while concomitantly initiating alternative anticoagulation. This can include rapidly effective factor Xa inhibitors or direct thrombin inhibitors.
机构:
Univ Massachusetts, Sch Med, Cardiovasc Thrombosis Res Ctr, Worcester, MA 01655 USAUniv Massachusetts, Sch Med, Cardiovasc Thrombosis Res Ctr, Worcester, MA 01655 USA
机构:
McMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, CanadaMcMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
Sheppard, Jo-Ann I.
Moore, Jane C.
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McMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
McMaster Univ, Dept Med, Michael G DeGroote Sch Med, Hamilton, ON, CanadaMcMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
Moore, Jane C.
Cook, Richard J.
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Univ Waterloo, Dept Stat & Actuarial Sci, Waterloo, ON N2L 3G1, CanadaMcMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
Cook, Richard J.
Kelton, John G.
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McMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
McMaster Univ, Dept Med, Michael G DeGroote Sch Med, Hamilton, ON, CanadaMcMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
机构:
Univ Massachusetts, Sch Med, Cardiovasc Thrombosis Res Ctr, Worcester, MA 01655 USAUniv Massachusetts, Sch Med, Cardiovasc Thrombosis Res Ctr, Worcester, MA 01655 USA
机构:
McMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, CanadaMcMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
Sheppard, Jo-Ann I.
Moore, Jane C.
论文数: 0引用数: 0
h-index: 0
机构:
McMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
McMaster Univ, Dept Med, Michael G DeGroote Sch Med, Hamilton, ON, CanadaMcMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
Moore, Jane C.
Cook, Richard J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Waterloo, Dept Stat & Actuarial Sci, Waterloo, ON N2L 3G1, CanadaMcMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
Cook, Richard J.
Kelton, John G.
论文数: 0引用数: 0
h-index: 0
机构:
McMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
McMaster Univ, Dept Med, Michael G DeGroote Sch Med, Hamilton, ON, CanadaMcMaster Univ, Dept Pathol & Mol Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada