Heparin-induced thrombocytopenia

被引:0
作者
Eichler, I. [1 ]
机构
[1] Klinikum Dortmund gGmbH, Klin Herzchirurg, Intens Stn, Beurhausstr 40, D-44137 Dortmund, Germany
来源
ZEITSCHRIFT FUR HERZ THORAX UND GEFASSCHIRURGIE | 2014年 / 28卷 / 02期
关键词
Platelet factor 4; Antibodies; Thrombosis; Anticoagulants; Cardiac surgical procedures;
D O I
10.1007/s00398-013-1060-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Heparin-induced thrombocytopenia (HIT) type II is caused by an immune response involving antibody formation to the heparin-platelet factor 4 complex. An activation of platelets leads to an uncontrolled generation of thrombin which in turn leads to arterial and/or venous thrombosis. Untreated this condition can result in loss of limbs or fulminant pulmonary embolism. As the main trigger is the administration of unfractionated heparin it is paramount to immediately stop heparinization while concomitantly initiating alternative anticoagulation. This can include rapidly effective factor Xa inhibitors or direct thrombin inhibitors.
引用
收藏
页码:127 / 132
页数:6
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