TRANSPLANTATION OF PORCINE FETAL PANCREAS TO DIABETIC-PATIENTS

被引：413

作者：

GROTH, CG

KORSGREN, O

TIBELL, A

TOLLEMAR, J

MOLLER, E

BOLINDER, J

OSTMAN, J

REINHOLT, FP

HELLERSTROM, C

ANDERSSON, A

机构：

[1] KAROLINSKA INST,HUDDINGE HOSP,DEPT MED,S-14106 HUDDINGE,SWEDEN

[2] KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN IMMUNOL,S-14106 HUDDINGE,SWEDEN

[3] KAROLINSKA INST,HUDDINGE HOSP,DEPT PATHOL,S-14106 HUDDINGE,SWEDEN

[4] UNIV UPPSALA,BIOCTR,DEPT MED CELL BIOL,UPPSALA,SWEDEN

来源：

LANCET | 1994年 / 344卷 / 8934期

关键词：

D O I：

10.1016/S0140-6736(94)90570-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transplanation of fetal porcine islet-like cell clusters (ICC) reverses diabetes in experimental animals. We have now transplanted porcine ICC to ten insulin-dependent diabetic kidney-transplant patients. A11 patients received standard immunosuppression and, at ICC transplantation, antithymocyte globulin or 15-deoxyspergualin. ICC were injected intraportally or placed under the kidney capsule of the renal graft. Four patients excreted small amounts of porcine C-peptide in urine for 200-400 days. In one renal-graft biopsy specimen, morphologically intact epithelial cells stained positively for insulin and glucagon in the subcapsular space. We conclude that porcine pancreatic endocrine tissue can survive in the human body.

引用

页码：1402 / 1404

页数：3

共 10 条

[1]

BJOERSDORFF A, 1992, TRANSPLANT P, V24, P674

[2] SENSITIVITY AND REPRODUCIBILITY OF URINARY C-PEPTIDE AS ESTIMATE OF ISLET B-CELL FUNCTION IN INSULIN-TREATED DIABETES [J].