Heparanase tailors syndecan for exosome production

被引：26

作者：

David, Guido ^{[1
]}

Zimmermann, Pascale ^{[2
,3
,4
]}

机构：

[1] Katholieke Univ Leuven, Dept Human Genet, Lab Glycobiol & Dev Genet, Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Human Genet, Lab Signal Integrat Cell Fate Decis, Leuven, Belgium

[3] Aix Marseille Univ, CRCM, F-13284 Marseille, France

[4] Inst Paoli Calmettes, CNRS, INSERM, U1068,UMR7258, Marseille, France

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 03期

关键词：

ALIX; ESCRT; exosome; exosomal cargo; heparan sulfate; heparanase; PDZ domains; syndecan; syntenin; tumor progression;

D O I：

10.1080/23723556.2015.1047556

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Exosomes are secreted vesicles involved in signaling processes. The biogenesis of a class of these vesicles depends on syntenin and syndecans. Heparanase acts as a regulator of the syndecan-syntenin-exosome biogenesis pathway. The upregulation of syntenin and heparanase in cancers may support the suspected roles of exosomes in tumor biology.

引用

页数：3

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