Cancer stem cells and HER2 positive breast cancer: The story so far

被引：43

作者：

Shah, Deep ^{[1
]}

Osipo, Clodia ^{[2
]}

机构：

[1] Loyola Univ Chicago, Dept Mol Pharmacol & Therapeut, Oncol Res Inst, Maywood, IL 60153 USA

[2] Loyola Univ Chicago, Dept Microbiol & Immunol, Oncol Res Inst, Maywood, IL 60153 USA

来源：

GENES & DISEASES | 2016年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Breast cancer; Cancer stem cells (CSCs); Drug resistance; Human epidermal growth factor receptor type 2 (HER2); Signaling pathways;

D O I：

10.1016/j.gendis.2016.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human Epidermal Growth Factor Receptor type 2 (HER2) gene amplification and/or protein overexpression is observed in patients suffering from HER2+ breast cancer. This subtype of breast cancer has improved prognosis due to availability of anti-HER2 therapy. However, drug resistance and tumor recurrence still remains a major concern. Cancer Stem Cells (CSCs) are believed to constitute the subset of cell population that is resistant to drug treatment and possesses characteristics of stem cells. CSCs enable the tumors to thrive despite major insults. This review provides a comprehensive idea about the concept of CSCs in context of HER2+ breast cancer by providing the description of the markers that are used for the identification of CSCs and by elucidating the signaling pathways that are associated with HER2+ breast CSCs. Furthermore, the review also describes the interaction of HER2 with those signaling pathways and the future of targeting CSCs in HER2+ breast cancer. Copyright (C) 2016, Chongqing Medical University. Production and hosting by Elsevier B.V.

引用

页码：114 / 123

页数：10

共 59 条

[1] Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy [J].

Abravanel, Daniel L. ;

Belka, George K. ;

Pan, Tien-chi ;

Pant, Dhruv K. ;

Collins, Meredith A. ;

Sterner, Christopher J. ;

Chodosh, Lewis A. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (06) :2484-2496

[2] Dormancy in breast cancer [J].

Banys, Malgorzata ;

Hartkopf, Andreas D. ;

Krawczyk, Natalia ;

Kaiser, Tatjana ;

Meier-Stiegen, Franziska ;

Fehm, Tanja ;

Neubauer, Hans .

BREAST CANCER-TARGETS AND THERAPY, 2012, 4 :183-191

[3] IκB kinase a kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells [J].

Cao, Yixue ;

Luo, Jun-Li ;

Karin, Michael .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (40) :15852-15857

[4] Trastuzumab-Resistant Cells Rely on a HER2-PI3K-FoxO-Survivin Axis and Are Sensitive to PI3K Inhibitors [J].

Chakrabarty, Anindita ;

Bhola, Neil E. ;

Sutton, Cammie ;

Ghosh, Ritwik ;

Kuba, Maria Gabriela ;

Dave, Bhuvanesh ;

Chang, Jenny C. ;

Arteaga, Carlos L. .

CANCER RESEARCH, 2013, 73 (03) :1190-1200

[5] STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits [J].

Chung, Seyung S. ;

Giehl, Nolan ;

Wu, Yanyuan ;

Vadgama, Jaydutt V. .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (02) :403-411

[6] Mechanisms of lapatinib resistance in HER2-driven breast cancer [J].

D'Amato, Valentina ;

Raimondo, Lucia ;

Formisano, Luigi ;

Giuliano, Mario ;

De Placido, Sabino ;

Rosa, Roberta ;

Bianco, Roberto .

CANCER TREATMENT REVIEWS, 2015, 41 (10) :877-883

[7] Targeting of preexisting and induced breast cancer stem cells with trastuzumab and trastuzumab emtansine (T-DM1) [J].

Diessner, J. ;

Bruttel, V. ;

Stein, R. G. ;

Horn, E. ;

Haeusler, S. F. M. ;

Dietl, J. ;

Hoenig, A. ;

Wischhusen, J. .

CELL DEATH & DISEASE, 2014, 5 :e1149-e1149

[8] HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells [J].

Duru, Nadire ;

Fan, Ming ;

Candas, Demet ;

Menaa, Cheikh ;

Liu, Hsin-Chen ;

Nantajit, Danupon ;

Wen, Yunfei ;

Xiao, Kai ;

Eldridge, Angela ;

Chromy, Brett A. ;

Li, Shiyong ;

Spitz, Douglas R. ;

Lam, Kit S. ;

Wicha, Max S. ;

Li, Jian Jian .

CLINICAL CANCER RESEARCH, 2012, 18 (24) :6634-6647

[9] The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis [J].

Flemban, Arwa ;

Qualtrough, David .

CANCERS, 2015, 7 (03) :1863-1884

[10] The therapeutic promise of the cancer stem cell concept [J].

Frank, Natasha Y. ;

Schatton, Tobias ;

Frank, Markus H. .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (01) :41-50

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