Bleeding with oral anticoagulant dabigatran is highly associated with occult cancers in atrial fibrillation patients

被引：4

作者：

Koike, Hideki ^{[1
]}

Fujino, Tadashi ^{[1
]}

Koike, Makiko ^{[1
]}

Yao, Shintaro ^{[1
]}

Akitsu, Katsuya ^{[1
]}

Shinohara, Masaya ^{[1
]}

Yuzawa, Hitomi ^{[1
]}

Suzuki, Takeya ^{[1
]}

Ikeda, Takanori ^{[1
]}

机构：

[1] Toho Univ, Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan

来源：

FUTURE CARDIOLOGY | 2018年 / 14卷 / 01期

关键词：

atrial fibrillation; bleeding; dabigatran; direct oral anticoagulant; gastrointestinal cancers;

D O I：

10.2217/fca-2017-0063

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: The aim of this study was to examine cancer and bleeding in atrial fibrillation patients administered with dabigatran. Materials & methods: This study enrolled 509 consecutive nonvalvular atrial fibrillation patients who received dabigatran. The mean administration period was 14.8 +/- 15.7 months. We investigated the prevalence and new development of cancers. Further, the relation between cancer and adverse events was evaluated. Results: In the 509 patients, major bleeding occurred in 2.6% and dyspepsia in 8.4%. Further, 16.9% patients had a history of cancer and 3.9% developed new cancers. These adverse events developed in 45% patients who developed new cancers. The cancer (hazard ratio: 6.30; p = 0.003) was a significant predictor of major bleeding. Conclusion: Bleeding was associated with the presence of cancer.

引用

页码：27 / 36

页数：10

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