CIMETIDINE DOES NOT IMPAIR PULMONARY CLEARANCE OF PSEUDOMONAS-AERUGINOSA IN NORMAL RATS

被引：2

作者：

DAON, E ^{[1
]}

SUMMER, W ^{[1
]}

NELSON, S ^{[1
]}

MASON, C ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV,MED CTR,NEW ORLEANS,LA 70112

来源：

DIGESTIVE DISEASES AND SCIENCES | 1994年 / 39卷 / 07期

关键词：

NOSOCOMIAL PNEUMONIA; STRESS BLEEDING; H-2; ANTAGONIST; LUNG BACTERIAL CLEARANCE;

D O I：

10.1007/BF02088050

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Histamine (H-2)-receptor blockers are commonly used in critically ill patients to prevent gastric bleeding and have been implicated in the pathogenesis of gram-negative bacterial (GNB) nosocomial pneumonia. These experiments were undertaken to determine if cimetidine affects pulmonary GNB clearance. Groups of normal Sprague-Dawley rats were given cimetidine (75 mg/kg) or an equal volume of sterile buffer intraperitoneally every 6 hr for 24 hr prior to intratracheal challenge with 1.0 x 10(8) Pseudomonas aeruginosa. At 6 and 24 hr after challenge, animals were sacrificed and gastric pH, quantitative lung cultures, and total and differential [alveolar macrophages (AM) and polymorphonuclear leukocytes (PMN)] cell counts in bronchoalveolar lavage fluid were performed. Results showed that cimetidine therapy resulting in gastric pH greater than 4.0 has no effect on the pulmonary clearance of P. aeruginosa.

引用

页码：1469 / 1472

页数：4

共 31 条

[21]

NELSON S, 1985, AM REV RESPIR DIS, V131, P923

[22] COMPARTMENTALIZATION OF INTRAALVEOLAR AND SYSTEMIC LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR AND THE PULMONARY INFLAMMATORY RESPONSE [J].