SH2 AND SH3 DOMAINS AS MOLECULAR ADHESIVES - THE INTERACTIONS OF CRK AND ABL

被引：192

作者：

FELLER, SM ^{[1
]}

REN, RB ^{[1
]}

HANAFUSA, H ^{[1
]}

BALTIMORE, D ^{[1
]}

机构：

[1] MIT, CAMBRIDGE, MA 02139 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 11期

关键词：

D O I：

10.1016/0968-0004(94)90129-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Src homology domains SH2 and SH3 are modular components present in many signal transduction proteins. They allow rapid formation of stable protein complexes and may also regulate protein function through intramolecular binding events. SH2 domains recognize phosphotyrosyl residues in a specific sequence context, while SH3 domains recognize a PxxP motif and additional residues that mediate binding specificity.

引用

收藏

页码：453 / 458

页数：6

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