SH2 AND SH3 DOMAINS AS MOLECULAR ADHESIVES - THE INTERACTIONS OF CRK AND ABL

被引：192

作者：

FELLER, SM ^{[1
]}

REN, RB ^{[1
]}

HANAFUSA, H ^{[1
]}

BALTIMORE, D ^{[1
]}

机构：

[1] MIT, CAMBRIDGE, MA 02139 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 11期

关键词：

D O I：

10.1016/0968-0004(94)90129-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Src homology domains SH2 and SH3 are modular components present in many signal transduction proteins. They allow rapid formation of stable protein complexes and may also regulate protein function through intramolecular binding events. SH2 domains recognize phosphotyrosyl residues in a specific sequence context, while SH3 domains recognize a PxxP motif and additional residues that mediate binding specificity.

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收藏

页码：453 / 458

页数：6

相关论文

共 38 条

[1] DIFFERENTIAL COMPLEMENTATION OF BCR-ABL POINT MUTANTS WITH C-MYC [J].

AFAR, DEH ;

GOGA, A ;

MCLAUGHLIN, J ;

WITTE, ON ;

SAWYERS, CL .

SCIENCE, 1994, 264 (5157) :424-426

[2] IDENTIFICATION AND CHARACTERIZATION OF A HIGH-AFFINITY INTERACTION BETWEEN V-CRK AND TYROSINE-PHOSPHORYLATED PAXILLIN IN CT10-TRANSFORMED FIBROBLASTS [J].

BIRGE, RB ;

FAJARDO, JE ;

REICHMAN, C ;

SHOELSON, SE ;

SONGYANG, Z ;

CANTLEY, LC ;

HANAFUSA, H .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (08) :4648-4656

[3] EPIDERMAL GROWTH-FACTOR REGULATES P21(RAS) THROUGH THE FORMATION OF A COMPLEX OF RECEPTOR, GRB2 ADAPTER PROTEIN, AND SOS NUCLEOTIDE EXCHANGE FACTOR [J].

BUDAY, L ;

DOWNWARD, J .

CELL, 1993, 73 (03) :611-620

[4] IDENTIFICATION OF A PROTEIN THAT BINDS TO THE SH3 REGION OF ABI AND IS SIMILAR TO BCR AND GAP-RHO [J].

CICCHETTI, P ;

MAYER, BJ ;

THIEL, G ;

BALTIMORE, D .

SCIENCE, 1992, 257 (5071) :803-806

[5] BINDING OF THE GRB2 SH2 DOMAIN TO PHOSPHOTYROSINE MOTIFS DOES NOT CHANGE THE AFFINITY OF ITS SH3 DOMAINS FOR SOS PROLINE-RICH MOTIFS [J].

CUSSAC, D ;

FRECH, M ;

CHARDIN, P .

EMBO JOURNAL, 1994, 13 (17) :4011-4021

[6]

DALEY GQ, 1991, ADV CANCER RES, V57, P151

[7] JAK-STAT PATHWAYS AND TRANSCRIPTIONAL ACTIVATION IN RESPONSE TO IFNS AND OTHER EXTRACELLULAR SIGNALING PROTEINS [J].

DARNELL, JE ;

KERR, IM ;

STARK, GR .

SCIENCE, 1994, 264 (5164) :1415-1421

[8] CLONING OF A GRB2 ISOFORM WITH APOPTOTIC PROPERTIES [J].

FATH, I ;

SCHWEIGHOFFER, F ;

REY, I ;

MULTON, MC ;

BOIZIAU, J ;

DUCHESNE, M ;

TOCQUE, B .

SCIENCE, 1994, 264 (5161) :971-974

[9] C-ABL KINASE REGULATES THE PROTEIN-BINDING ACTIVITY OF C-CRK [J].

FELLER, SM ;

KNUDSEN, B ;

HANAFUSA, H .

EMBO JOURNAL, 1994, 13 (10) :2341-2351

[10]

FELLER SM, IN PRESS METHODS ENZ

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