CARDIOTOXIC EFFECTS OF ASTEMIZOLE OVERDOSE IN CHILDREN

被引：66
作者：
WILEY, JF
GELBER, ML
HENRETIG, FM
WILEY, CC
SANDHU, S
LOISELLE, J
机构：
[1] CHILDRENS HOSP PHILADELPHIA, DIV GEN PEDIAT, PHILADELPHIA, PA USA
[2] ST CHRISTOPHERS HOSP CHILDREN, CARDIOL SECT, PHILADELPHIA, PA 19133 USA
[3] DELAWARE VALLEY REG POISON CONTROL CTR, PHILADELPHIA, PA USA
来源：
JOURNAL OF PEDIATRICS | 1992年 / 120卷 / 05期
关键词：
D O I：
10.1016/S0022-3476(05)80252-5
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an average of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electrocardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.
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收藏
页码：799 / 802
页数：4
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