ANTIBIOTIC-PROPHYLAXIS FOLLOWING LOWER URINARY-TRACT INSTRUMENTATION

被引：5

作者：

BHATIA, NN

KARRAM, MM

BERGMAN, A

EVANS, RP

机构：

[1] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DIV GYNECOL UROL,TORRANCE,CA 90509

[2] UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,LOS ANGELES,CA 90048

来源：

UROLOGY | 1992年 / 39卷 / 06期

关键词：

D O I：

10.1016/0090-4295(92)90024-Q

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The value of routine antibiotic prophylaxis was assessed in 362 women undergoing lower urinary tract instrumentation. A three-day course of a once-a-day dose of 1 g of cefadroxil was compared with a three-day course of 100 mg of nitrofurantoin three times a day, in a randomized investigator blinded placebo controlled study. Both study drugs were significantly more effective in preventing postinstrumentation urinary tract infections than placebo (p < 0.003). Differences in efficacy between the two test drugs were not significant; however, side effects in the nitrofurantoin group were more frequent and severe than those in the cefadroxil group. Cefadroxil also offered the advantage of a once-daily dosing schedule.

引用

页码：583 / 585

页数：3