POSTNATAL-DEVELOPMENT OF MESSENGER-RNA SPECIFIC FOR A METABOTROPIC GLUTAMATE RECEPTOR IN THE RAT-BRAIN

被引：22

作者：

MINAKAMI, R

HIROSE, E

YOSHIOKA, K

YOSHIMURA, R

MISUMI, Y

SAKAKI, Y

TOHYAMA, M

KIYAMA, H

SUGIYAMA, H

机构：

[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,6-10-1 HAKOZAKI,HIGASHI KU,FUKUOKA 812,JAPAN

[2] KYUSHU UNIV,GENET INFORMAT RES LAB,HIGASHI KU,FUKUOKA 812,JAPAN

[3] OSAKA UNIV,SCH MED,DEPT ANAT 2,SUITA,OSAKA 565,JAPAN

[4] FUKUOKA UNIV,SCH MED,DEPT BIOCHEM,FUKUOKA 81401,JAPAN

来源：

NEUROSCIENCE RESEARCH | 1992年 / 15卷 / 1-2期

关键词：

EXCITATORY AMINO ACID; GLUTAMATE RECEPTOR; METABOTROPIC GLUTAMATE RECEPTOR; DEVELOPMENT; HIPPOCAMPUS; CEREBELLUM; OLFACTORY BULB; CEREBRAL CORTEX;

D O I：

10.1016/0168-0102(92)90017-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the ontogenesis of a subtype of metabotropic glutamate receptors, termed mGluR1, which is linked to phosphoinositide metabolism, in various regions of rat brain during neonatal development. Northern blot analyses of mGluR1 mRNA indicated that mRNA increased monotonously or remained at plateau levels during the first 5 weeks after birth. In situ hybridization analyses supported this conclusion. The result is in contrast with the reported development of the activity in excitatory amino acid-stimulated phosphoinositide turnover during the same period. The latter increases during the first few weeks and then decreases sharply.

引用

页码：58 / 63

页数：6

共 13 条

[1]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[2] POSTNATAL CHANGES IN GLUTAMATE STIMULATED PHOSPHOINOSITIDE TURNOVER IN RAT NEOCORTICAL SYNAPTONEUROSOMES [J].