RESPONSE TO TUMOR-NECROSIS-FACTOR IN 2 CASES OF PSORIASIS

被引：19
|
作者：
CREAVEN, PJ [1 ]
STOLL, HL [1 ]
机构：
[1] NEW YORK STATE DEPT HLTH,ROSWELL PK CANC INST,DEPT DERMATOL,BUFFALO,NY 14263
来源：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1991年 / 24卷 / 05期
关键词：
D O I：
10.1016/0190-9622(91)70112-F
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
A 70-year-old woman was treated for renal cell carcinoma with recombinant human tumor necrosis factor, 450,000 U/m2 of body surface area, daily for 5 days, once a month. She had had psoriasis for 25 years. After two courses of recombinant human tumor necrosis factor her psoriasis resolved. A 40-year-old man with severe psoriasis was subsequently treated with a total of seven complete and incomplete 5-day courses of recombinant human tumor necrosis factor at doses of 50,000 to 300,000 U/m2/day. Significant toxicity (fever, chills, hypertension, and hypotension) was encountered. Partial resolution of the lesions was seen. Tumor necrosis factor is an active agent in psoriasis.
引用
收藏
页码：735 / 737
页数：3
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