RESPONSE TO TUMOR-NECROSIS-FACTOR IN 2 CASES OF PSORIASIS

被引：19
|
作者：
CREAVEN, PJ [1 ]
STOLL, HL [1 ]
机构：
[1] NEW YORK STATE DEPT HLTH,ROSWELL PK CANC INST,DEPT DERMATOL,BUFFALO,NY 14263
来源：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1991年 / 24卷 / 05期
关键词：
D O I：
10.1016/0190-9622(91)70112-F
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
A 70-year-old woman was treated for renal cell carcinoma with recombinant human tumor necrosis factor, 450,000 U/m2 of body surface area, daily for 5 days, once a month. She had had psoriasis for 25 years. After two courses of recombinant human tumor necrosis factor her psoriasis resolved. A 40-year-old man with severe psoriasis was subsequently treated with a total of seven complete and incomplete 5-day courses of recombinant human tumor necrosis factor at doses of 50,000 to 300,000 U/m2/day. Significant toxicity (fever, chills, hypertension, and hypotension) was encountered. Partial resolution of the lesions was seen. Tumor necrosis factor is an active agent in psoriasis.
引用
收藏
页码：735 / 737
页数：3
相关论文
共 50 条
  • [1] REGULATION OF CELL RESPONSE TO TUMOR-NECROSIS-FACTOR
    WALLACH, D
    NOPHAR, Y
    ADERKA, D
    ISRAEL, S
    HAHN, T
    ENGELMANN, H
    HOLTMANN, H
    IMMUNOBIOLOGY, 1987, 175 (1-2) : 42 - 42
  • [2] TUMOR-NECROSIS-FACTOR
    WILSON, AG
    DUFF, GW
    LANCET, 1995, 345 (8950): : 649 - 649
  • [3] TUMOR-NECROSIS-FACTOR
    WAKEFIELD, PE
    JAMES, WD
    SAMLASKA, CP
    MELTZER, MS
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1991, 24 (05) : 675 - 685
  • [4] TUMOR-NECROSIS-FACTOR
    JONES, A
    TRANSFUSION SCIENCE, 1991, 12 (1-2): : 67 - 73
  • [5] EFFECT OF TUMOR-NECROSIS-FACTOR IN THE MOUSE-TAIL MODEL OF PSORIASIS
    NAGANO, K
    HORI, K
    NAGANE, T
    SUGAWARA, T
    OHISHI, J
    HAYASHI, H
    WATANABE, N
    NIITSU, Y
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 1990, 282 (07) : 459 - 462
  • [6] PHOSPHOLIPASE-A2 ACTIVATION AND AUTOINDUCTION OF TUMOR-NECROSIS-FACTOR GENE-EXPRESSION BY TUMOR-NECROSIS-FACTOR
    SPRIGGS, DR
    SHERMAN, ML
    IMAMURA, K
    MOHRI, M
    RODRIGUEZ, C
    ROBBINS, G
    KUFE, DW
    CANCER RESEARCH, 1990, 50 (22) : 7101 - 7107
  • [7] NONHEMATOPOIETIC CELLS SELECTED FOR RESISTANCE TO TUMOR-NECROSIS-FACTOR PRODUCE TUMOR-NECROSIS-FACTOR
    RUBIN, BY
    ANDERSON, SL
    SULLIVAN, SA
    WILLIAMSON, BD
    CARSWELL, EA
    OLD, LJ
    JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (04): : 1350 - 1355
  • [8] THROMBOSPONDIN AND TUMOR-NECROSIS-FACTOR
    DIXIT, VM
    KIDNEY INTERNATIONAL, 1992, 41 (03) : 679 - 682
  • [9] TUMOR-NECROSIS-FACTOR AND IMMUNOPATHOLOGY
    PIGUET, PF
    GRAU, GE
    VASSALLI, P
    IMMUNOLOGIC RESEARCH, 1991, 10 (02) : 122 - 140
  • [10] TUMOR-NECROSIS-FACTOR AND ADRENOLEUKODYSTROPHY
    MCGUINNESS, MC
    GRIFFIN, DE
    MOSER, HW
    SMITH, KD
    JOURNAL OF NEUROCHEMISTRY, 1994, 62 : S104 - S104
12345