IRREVERSIBLE ENZYME INHIBITORS .178. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE DERIVED FROM 1-(4-BENZYLOXY-3-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE WITH A TERMINAL SULFONYL FLUORIDE

被引：4

作者：

BAKER, BR

ASHTON, WT

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1970年 / 13卷 / 06期

关键词：

D O I：

10.1021/jm00300a031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1161 / &

共 17 条

[1] IRREVERSIBLE ENZYME INHIBITORS .160. SOME FACTORS IN CELL WALL TRANSPORT OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-L-(PHENYLALKYLPHENYL)-S-TRIAZINES [J].

BAKER, BR ;

JANSON, EE ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) :898-+

[2] IRREVERSIBLE ENZYME INHIBITORS .150. PROTEOLYTIC ENZYMES .9. (3,4-DICHLOROPHENOXYACETAMIDO)PYRIDINES BRIDGED BY A QUATERNARY SALT TO A TERMINAL SULFONYL FLUORIDE . POTENT IRREVERSIBLE INHIBITORS OF ALPHA-CHYMOTRYPSIN [J].

BAKER, BR ;

HURLBUT, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (02) :221-&

[3]

BAKER BR, 1968, J MED CHEM, V11, P666, DOI 10.1021/jm00310a007

[4] IRREVERSIBLE ENZYME INHIBITORS .161. PROTEOLYTIC ENZYMES .13. INHIBITORS OF GUINEA PIG COMPLEMENT DERIVED BY QUATERNIZATION OF 3-ACYLAMIDOPYRIDINES WITH ALPHA-BROMOMETHYLBENZENESULFONYL FLUORIDES .2. [J].

BAKER, BR ;

HURLBUT, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) :902-&

[5] IRREVERSIBLE ENZYME INHIBITORS .176. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINE BY ETHER BRIDGING TO A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

ASHTON, WT .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) :1149-&

[6] IRREVERSIBLE ENZYME INHIBITORS .175. IRREVERSIBLE INHIBITION OF PURIFIED DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) :1143-+

[7] IRREVERSIBLE ENZYME INHIBITORS .166. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)PYRIMIDINE WITH 6 SUBSTITUENTS AND SOME FACTORS IN THEIR CELL WALL TRANSPORT [J].

BAKER, BR ;

VERMEULE.NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (01) :82-&

[8] IRREVERSIBLE ENZYME INHIBITORS .154. SOME FACTORS IN CELL WALL TRANSPORT OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 5-SUBSTITUTED 2,4-DIAMINOPYRIMIDINES [J].

BAKER, BR ;

MEYER, RB .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (04) :668-&

[9] IRREVERSIBLE ENZYME INHIBITORS . 140 . ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS DERIVED FROM 1-(3-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :95-&

[10] IRREVERSIBLE ENZYME INHIBITORS . 133 . STUDIES ON DIFFERENTIAL IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM 3 STRAINS OF L1210 LEUKEMIA LIVER SPLEEN AND INTESTINE OF MOUSE [J].

BAKER, BR ;

LOURENS, GJ ;

MEYER, RB ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :67-+

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