CHLORIDE-ION PLAYS AN IMPORTANT ROLE IN SODIUM INDUCED VOLUME EXPANSION IN NORMAL HUMANS

被引：7
作者：
TOMITA, Y
UENO, M
TSUCHIHASHI, T
MURATANI, H
KOBAYASHI, K
TAKISHITA, S
FUJISHIMA, M
机构：
[1] The Second Department of Internal Medicine, Kyushu University, Fukuoka
来源：
AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 06期
关键词：
Blood volume; Chloride; Citrate; Norepinephrine; Renin; Sodium;
D O I：
10.1093/ajh/3.6.485
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Eight normal women took part in a randomized crossover study to investigate the effect of dietary supplementation with 105 mEq sodium chloride (NaCl) for 3 days or equimolar sodium citrate (NaCit) after salt depletion. NaCit supplement induced greater urinary sodium and potassium excretions than did the NaCl supplement (197 ± 10 v 107 ± 19 mEq/3 days for sodium, P <. 01, 130 ± 7 v 96 ± 6 mEq/3 days for potassium, P <. 01, respectively) and less body weight gain (+0.6 ± 0.1 v +1.6 ± 0.1 kg, P <. 01). Suppressions of plasma norepinephrine, renin activity and aldosterone concentration were significantly smaller with NaCit than with NaCl supplement. We conclude that the an-ionic component of sodium salts may have some effects on renal sodium handling and modulates volume expansion and humoral factors. © 1990 by the American Journal of Hypertension, Ltd.
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页码：485 / 487
页数：3
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