OPIOID PEPTIDES MODULATE LUTEINIZING-HORMONE SECRETION DURING SEXUAL-MATURATION

被引：242
作者：
BLANK, MS
PANERAI, AE
FRIESEN, HG
机构：
[1] Department of Physiology, University of Manitoba, Faculty of Medicine, Winnipeg
来源：
SCIENCE | 1979年 / 203卷 / 4385期
关键词：
D O I：
10.1126/science.424743
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation. Copyright © 1979 AAAS.
引用
收藏
页码：1129 / 1131
页数：3
相关论文
共 18 条
[1]   OPIATE ANALGESICS - EFFECT OF AGONIST-ANTAGONIST CHARACTER ON PROLACTIN SECRETION [J].
BROWN, B ;
DETTMAR, PW ;
DOBSON, PR ;
LYNN, AG ;
METCALF, G ;
MORGAN, BA .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1978, 30 (10) :644-645
[2]   EFFECTS OF NALOXONE, MORPHINE AND METHIONINE ENKEPHALIN ON SERUM PROLACTIN, LUTEINIZING-HORMONE, FOLLICLE-STIMULATING HORMONE, THYROID STIMULATING HORMONE AND GROWTH-HORMONE [J].
BRUNI, JF ;
VANVUGT, D ;
MARSHALL, S ;
MEITES, J .
LIFE SCIENCES, 1977, 21 (03) :461-466
[3]   ESTROGENIC REGULATION OF CYTOPLASMIC-RECEPTOR POPULATIONS IN ESTROGEN-RESPONSIVE TISSUES OF RAT [J].
CIDLOWSKI, JA ;
MULDOON, TG .
ENDOCRINOLOGY, 1974, 95 (06) :1621-1629
[4]   STUDIES ON PITUITARY RESPONSIVENESS TO LUTEINIZING HORMONE RELEASING HORMONE (LH-RH) IN INTACT MALE RATS OF DIFFERENT AGES [J].
DEBELJUK, L ;
SCHALLY, AV ;
ARIMURA, A .
ENDOCRINOLOGY, 1972, 90 (02) :585-&
[5]   PITUITARY RESPONSIVENESS TO LH-RELEASING HORMONE IN INTACT FEMALE RATS OF DIFFERENT AGES [J].
DEBELJUK, L ;
SCHALLY, AV ;
ARIMURA, A .
ENDOCRINOLOGY, 1972, 90 (06) :1499-&
[6]  
DOHLER KD, 1975, ENDOCRINOLOGY, V97, P898
[7]   MULTIPLE RANGE AND MULTIPLE F TESTS [J].
DUNCAN, DB .
BIOMETRICS, 1955, 11 (01) :1-42
[8]   STIMULATION OF PROLACTIN-RELEASE IN RAT BY INTRAVENTRICULAR-INJECTION OF BETA-ENDORPHIN AND METHIONINE-ENKEPHALIN [J].
DUPONT, A ;
CUSAN, L ;
LABRIE, F ;
COY, DH ;
LI, CH .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 75 (01) :76-82
[9]   DEVELOPMENT OF HYPOTHALAMO-PITUITARY AXIS IN NEONATAL RAT - SEXUAL-MATURATION IN MALE AND FEMALE RATS AS ASSESSED BY HYPOTHALAMIC LHRH AND PITUITARY AND SERUM LH AND FSH CONCENTRATIONS [J].
DUSSAULT, JH ;
WALKER, P ;
DUBOIS, JD ;
LABRIE, F .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1977, 55 (05) :1091-1097
[10]   REGULATION OF PROLACTIN-RELEASE BY ENDOGENOUS OPIATES [J].
GRANDISON, L ;
GUIDOTTI, A .
NATURE, 1977, 270 (5635) :357-359
12