IMMUNOHISTOCHEMICAL LOCALIZATION OF THE NEURON-SPECIFIC GLUCOSE-TRANSPORTER (GLUT3) TO NEUROPIL IN ADULT-RAT BRAIN

被引：73
作者：
MCCALL, AL
VANBUEREN, AM
MOHOLTSIEBERT, M
CHERRY, NJ
WOODWARD, WR
机构：
[1] OREGON HLTH SCI UNIV,DEPT CELL BIOL,PORTLAND,OR 97201
[2] OREGON HLTH SCI UNIV,DEPT ANAT,PORTLAND,OR 97201
[3] DEPT VET AFFAIRS,DIABET PROGRAM,PORTLAND,OR 97201
[4] OREGON HLTH SCI UNIV,DEPT MED,DIV METAB ENDOCRINOL & NUTR,PORTLAND,OR 97201
[5] OREGON HLTH SCI UNIV,DEPT NEUROL,PORTLAND,OR 97201
来源：
BRAIN RESEARCH | 1994年 / 659卷 / 1-2期
关键词：
SYNAPSE; GLUCOSE TRANSPORTER; BRAIN METABOLISM; IMMUNOCYTOCHEMISTRY; ENERGY METABOLISM;
D O I：
10.1016/0006-8993(94)90896-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The precise histologic localization of GLUT3, a glucose transporter thought to be restricted to neurons, is unknown. Using a high-affinity, specific antiserum against rodent GLUT3 for immunocytochemistry, light microscopic staining concentrates heterogeneously in the neuropil in a region- and lamina-specific manner; intense staining characterizes areas with high rates of glucose utilization such as inferior colliculus and pyriform cortex. Neuropil localization with little perikaryal staining suggests that GLUT3 may provide the energy needed locally for synaptic transmission.
引用
收藏
页码：292 / 297
页数：6
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