Bedaquiline: A Novel Antitubercular Agent for the Treatment of Multidrug-Resistant Tuberculosis

被引：19

作者：

Yadav, Sankalp ^{[1
]}

Rawal, Gautam ^{[2
]}

Baxi, Mudit ^{[3
]}

机构：

[1] North Delhi Municipal Corp, Dept Med & TB, Chest Clin Moti Nagar, New Delhi 110015, India

[2] Max Super Specialty Hosp, Resp Intens Care, Care, New Delhi, India

[3] Sri Aurobindo Inst Med Coll & Postgrad Inst, Dept Orthoped, Indore, Madhya Pradesh, India

来源：

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH | 2016年 / 10卷 / 08期

关键词：

ATP Synthase; Diarylquinoline; Drug-resistance;

D O I：

10.7860/JCDR/2016/19052.8286

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The developing countries are having an abruptly growing number of drug resistant tuberculosis cases. Multidrug-resistant tuberculosis (MDR-TB) is a type of TB in which the strain of Mycobacterium tuberculosis is resistant to at least Isoniazid and Rifampicin, the two most effective of the four first-line TB drugs (the other two drugs being Ethambutol and Pyrazinamide). The management of such cases is complex and requires a treatment for 24-27 months. The current guidelines available for the management of this type of TB are largely based on the second line TB drugs which are relatively costly, less efficacious and are associated with greater side-effects. The introduction of newer drugs to cater to the high mortality and early sputum culture conversion in the MDR-TB cases is an absolute essential. In the present article, the authors discuss about the introduction of a newer drug named Bedaquiline for the control of MDR-TB.

引用

页码：FM1 / FM2

页数：2

共 16 条

[1] Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients [J].

Ahuja, Shama D. ;

Ashkin, David ;

Avendano, Monika ;

Banerjee, Rita ;

Bauer, Melissa ;

Bayona, Jamie N. ;

Becerra, Mercedes C. ;

Benedetti, Andrea ;

Burgos, Marcos ;

Centis, Rosella ;

Chan, Eward D. ;

Chiang, Chen-Yuan ;

Cox, Helen ;

D'Ambrosio, Lia ;

DeRiemer, Kathy ;

Nguyen Huy Dung ;

Enarson, Donald ;

Falzon, Dennis ;

Flanagan, Katherine ;

Flood, Jennifer ;

Garcia-Garcia, Maria L. ;

Gandhi, Neel ;

Granich, Reuben M. ;

Hollm-Delgado, Maria G. ;

Holtz, Timothy H. ;

Iseman, Michael D. ;

Jarlsberg, Leah G. ;

Keshavjee, Salmaan ;

Kim, Hye-Ryoun ;

Koh, Won-Jung ;

Lancaster, Joey ;

Lange, Christophe ;

de lange, Wiel C. M. ;

Leimane, Vaira ;

Leung, Chi Chiu ;

Li, Jiehui ;

Menzies, Dick ;

Migliori, Giovanni B. ;

Mishustin, Sergey P. ;

Mitnick, Carole D. ;

Narita, Masa ;

O'Riordan, Philly ;

Pai, Madhukar ;

Palmero, Domingo ;

Park, Seung-kyu ;

Pasvol, Geoffrey ;

Pena, Jose ;

Perez-Guzman, Carlos ;

Quelapio, Maria I. D. ;

Ponce-de-Leon, Alfredo .

PLOS MEDICINE, 2012, 9 (08)

[2] A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis [J].

Andries, K ;

Verhasselt, P ;

Guillemont, J ;

Göhlmann, HWH ;

Neefs, JM ;

Winkler, H ;

Van Gestel, J ;

Timmerman, P ;

Zhu, M ;

Lee, E ;

Williams, P ;

de Chaffoy, D ;

Huitric, E ;

Hoffner, S ;

Cambau, E ;

Truffot-Pernot, C ;

Lounis, N ;

Jarlier, V .

SCIENCE, 2005, 307 (5707) :223-227

[3] Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline [J].

Andries, Koen ;

Villellas, Cristina ;

Coeck, Nele ;

Thys, Kim ;

Gevers, Tom ;

Vranckx, Luc ;

Lounis, Nacer ;

de Jong, Bouke C. ;

Koul, Anil .

PLOS ONE, 2014, 9 (07)

[4] Bedaquiline: A new drug approved for treatment of multidrug-resistant tuberculosis [J].

Deoghare, Shashank .

INDIAN JOURNAL OF PHARMACOLOGY, 2013, 45 (05) :536-U120

[5] A Review of the Evidence for Using Bedaquiline (TMC207) to Treat Multi-Drug Resistant Tuberculosis [J].

Fox G.J. ;

Menzies D. .

Infectious Diseases and Therapy, 2013, 2 (2) :123-144

[6]

Herriman R., BEDAQUILINE LAUNCHED

[7] Treatment Outcomes of Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-Analysis [J].

Johnston, James C. ;

Shahidi, Neal C. ;

Sadatsafavi, Mohsen ;

Fitzgerald, J. Mark .

PLOS ONE, 2009, 4 (09)

[8] Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis [J].

Koul, Anil ;

Vranckx, Luc ;

Dendouga, Najoua ;

Balemans, Wendy ;

Van den Wyngaert, Ilse ;

Vergauwen, Karen ;

Goehlmann, Hinrich W. H. ;

Willebrords, Rudy ;

Poncelet, Alain ;

Guillemont, Jerome ;

Bald, Dirk ;

Andries, Koen .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (37) :25273-25280

[9] Drug resistance beyond extensively drug-resistant tuberculosis: individual patient data meta-analysis [J].

Migliori, Giovanni Battista ;

Sotgiu, Giovanni ;

Gandhi, Neel R. ;

Falzon, Dennis ;

DeRiemer, Kathryn ;

Centis, Rosella ;

Hollm-Delgado, Maria-Graciela ;

Palmero, Domingo ;

Perez-Guzman, Carlos ;

Vargas, Mario H. ;

D'Ambrosio, Lia ;

Spanevello, Antonio ;

Bauer, Melissa ;

Chan, Edward D. ;

Schaaf, H. Simon ;

Keshavjee, Salmaan ;

Holtz, Timothy H. ;

Menzies, Dick .

EUROPEAN RESPIRATORY JOURNAL, 2013, 42 (01) :169-179

[10] Treatment outcomes among patients with multidrug-resistant tuberculosis: systematic review and meta-analysis [J].

Orenstein, Evan W. ;

Basu, Sonjay ;

Shah, N. Sarita ;

Andrews, Jason R. ;

Friedland, Gerald H. ;

Moll, Anthony P. ;

Gandhi, Neel R. ;

Galvani, Alison P. .

LANCET INFECTIOUS DISEASES, 2009, 9 (03) :153-161

← 1 2 →