Thinking about brain insulin resistance

被引：11
作者：
Ahmad, Reem M. Al Haj [1 ]
Al-Domi, Hayder A. [1 ]
机构：
[1] Univ Jordan, Fac Agr, Dept Nutr & Food Technol, Queen Rania St, Amman 11942, Jordan
来源：
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS | 2018年 / 12卷 / 06期
关键词：
Blood brain barrier (BBB); Neurons; Type 2 diabetes mellitus (T2DM); Type 3 diabetes mellitus (T3DM);
D O I：
10.1016/j.dsx.2018.05.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: Dementia and type 2 diabetes mellitus (T2DM) are two of the epidemics of our time; in which insulin resistance (IR) is playing the central role. Epidemiological studies found that different types of dementia development may be promoted by the presence of T2DM. Objectives: We aimed in this review to highlight the role of insulin and the IR in the brain as a pathophysiological factor of dementia development and also to expand our understanding of T2DM as a mediator of IR in the brain and to review the possible mechanisms of action that may explain the association. Methodology: A critical review of the relevant published English articles up to 2018, using PubMed, Google Scholar, Science Direct, ADI, and WHO database was carried out. Keywords were included insulin resistance, T3DM, T2DM, dementia, brain insulin resistance were used. Conclusion: The rapidly increased prevalence of dementia concurrently with T2DM and obesity need urgent action to illustrate guidelines for prevention, modifying, and treatment based on mechanistic studies. (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：1091 / 1094
页数：4
相关论文
共 36 条
[1]   Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums [J].
Arnold, Steven E. ;
Arvanitakis, Zoe ;
Macauley-Rambach, Shannon L. ;
Koenig, Aaron M. ;
Wang, Hoau-Yan ;
Ahima, Rexford S. ;
Craft, Suzanne ;
Gandy, Sam ;
Buettner, Christoph ;
Stoeckel, Luke E. ;
Holtzman, David M. ;
Nathan, David M. .
NATURE REVIEWS NEUROLOGY, 2018, 14 (03) :168-181
[2]   Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase-dependent mechanism [J].
Benomar, Y ;
Naour, N ;
Aubourg, A ;
Bailleux, V ;
Gertler, A ;
Djiane, J ;
Guerre-Millo, M ;
Taouis, M .
ENDOCRINOLOGY, 2006, 147 (05) :2550-2556
[3]   Cerebrospinal fluid insulin during non-neurological surgery [J].
Bromander, Sara ;
Anckarsater, Rolf ;
Ahren, Bo ;
Kristiansson, Marianne ;
Blennow, Kaj ;
Holmang, Agneta ;
Zetterberg, Henrik ;
Anckarsater, Henrik ;
Wass, Caroline E. .
JOURNAL OF NEURAL TRANSMISSION, 2010, 117 (10) :1167-1170
[4]  
Callisaya ML, 2017, ALZHEIMERS DEMENT, V13, pP1425
[5]   Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia [J].
Chatterjee, Saion ;
Peters, Sanne A. E. ;
Woodward, Mark ;
Mejia Arango, Silvia ;
Batty, G. David ;
Beckett, Nigel ;
Beiser, Alexa ;
Borenstein, Amy R. ;
Crane, Paul K. ;
Haan, Mary ;
Hassing, Linda B. ;
Hayden, Kathleen M. ;
Kiyohara, Yutaka ;
Larson, Eric B. ;
Li, Chung-Yi ;
Ninomiya, Toshiharu ;
Ohara, Tomoyuki ;
Peters, Ruth ;
Russ, Tom C. ;
Seshadri, Sudha ;
Strand, Bjorn H. ;
Walker, Rod ;
Xu, Weili ;
Huxley, Rachel R. .
DIABETES CARE, 2016, 39 (02) :300-307
[6]  
CLARKE DW, 1986, J NEUROCHEM, V47, P831
[7]   ANALYSIS OF TYROSINE-HYDROXYLASE AND INSULIN TRANSCRIPTS IN HUMAN NEUROENDOCRINE TISSUES [J].
COKER, GT ;
STUDELSKA, D ;
HARMON, S ;
BURKE, W ;
OMALLEY, KL .
MOLECULAR BRAIN RESEARCH, 1990, 8 (02) :93-98
[8]   Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I [J].
Davis, Wendy A. ;
Zilkens, Renate R. ;
Starkstein, Sergio E. ;
Davis, Timothy M. E. ;
Bruce, David G. .
DIABETOLOGIA, 2017, 60 (01) :89-97
[9]  
DEVASKAR SU, 1994, J BIOL CHEM, V269, P8445
[10]   Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia [J].
Diggs-Andrews, Kelly A. ;
Zhang, Xuezhao ;
Song, Zhentao ;
Daphna-Iken, Dorit ;
Routh, Vanessa H. ;
Fisher, Simon J. .
DIABETES, 2010, 59 (09) :2271-2280
1234