BIOSYNTHESIS OF COLLAGEN AND ITS DISORDERS .2.

被引：551
作者：
PROCKOP, DJ
KIVIRIKKO, KI
TUDERMAN, L
GUZMAN, NA
机构：
[1] Department of Biochemistry, College of Medicine, Dentistry of New Jersey-Rutgers Medical School, Piscataway
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 1979年 / 301卷 / 02期
关键词：
D O I：
10.1056/NEJM197907123010204
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
(Second of Two Parts) How Do Defects in Biosynthesis Explain Genetic Diseases of Collagen? There are many rare genetic diseases that involve connective tissues, such as skin and bone. As the information reviewed above about collagen structure and biosynthesis accumulated, biochemical data were quickly obtained to explain a number of genetic diseases in man on the basis of molecular defects in collagen biosynthesis. The biochemical data helped to define specific subtypes of some of these diseases. At the same time, study of several of these genetic diseases provided new information about the biosynthetic process itself. For example, shortly after lysyl. © 1979, Massachusetts Medical Society. All rights reserved.
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页码：77 / 85
页数：9
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