SUPERINFECTION EXCLUSION OF VACCINIA VIRUS IN VIRUS-INFECTED CELL-CULTURES

被引：48

作者：

CHRISTEN, L ^{[1
]}

SETO, J ^{[1
]}

NILES, EG ^{[1
]}

机构：

[1] SUNY BUFFALO, DEPT BIOCHEM, BUFFALO, NY 14214 USA

来源：

VIROLOGY | 1990年 / 174卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0042-6822(90)90051-R

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vaccinia virus-infected BSC 40 cells do not permit the replication of superinfecting vaccinia virus. The extent of superinfecting virus propagation depends on the time of superinfection; there is 90% exclusion by 4 hr after the initial infection, and more than 99% by 6 hr. When superinfection is attempted at 6 hr after infection, the superinfecting virus is incapable of carrying out DNA replication or early gene transcription, demonstrating that an early event in the virus life cycle is inhibited. The rate of adsorption of the superinfecting virus is unaltered which shows that exclusion is affected at a point between adsorption and early gene transcription. In order to exclude superinfection, the primary infecting virus does not require replication of its DNA or expression of its late genes but it must express one or more early genes. © 1990.

引用

页码：35 / 42

页数：8

共 27 条

[1] INHIBITION OF PROTEIN-SYNTHESIS BY VACCINIA VIRUS .3. THE EFFECT OF ULTRAVIOLET-IRRADIATED VIRUS ON THE INHIBITION OF PROTEIN-SYNTHESIS [J].