OLIVANIC ACIDS, A FAMILY OF BETA-LACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORY PROPERTIES PRODUCED BY STREPTOMYCES SPECIES .1. DETECTION, PROPERTIES AND FERMENTATION STUDIES

被引：78

作者：

BUTTERWORTH, D

COLE, M

HANSCOMB, G

ROLINSON, GN

机构：

[1] Detection, Properties And Fermentation Studies

[2] Beecham Pharmaceuticals Research Division Brockham Park, Betchworth

来源：

JOURNAL OF ANTIBIOTICS | 1979年 / 32卷 / 04期

关键词：

D O I：

10.7164/antibiotics.32.287

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The screening of soil actinomycetes for β-lactamase inhibitors is described. Using a plate test a number of strains of Streptomyces were found to produce β-lactamase inhibitory activity designated olivanic acid complex. Factors affecting the production of this complex by Streptomyces olivaceus ATCC 21379 are reported. The complex showed antibacterial activity and also inhibited a number of different types of β-lactamase in a progressive manner. Certain ampicillin-resistant bacteria are rendered sensitive to ampicillin in the presence of olivanic acid complex at a concentration which alone did not inhibit growth. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：287 / 294

页数：8

共 21 条

[1] NATURALLY-OCCURRING BETA-LACTAMASE INHIBITORS WITH ANTIBACTERIAL ACTIVITY [J].