A DOUBLE-BLIND, RANDOMIZED, PROSPECTIVE TRIAL OF A TOPICAL ANTISEPTIC VERSUS A TOPICAL ANTIBIOTIC IN THE TREATMENT OF OTORRHEA

被引：40

作者：

CLAYTON, MI

OSBORNE, JE

RUTHERFORD, D

RIVRON, RP

机构：

[1] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT EAR NOSE & THROAT,DUNDEE DD1 9SY,SCOTLAND

[2] UNIV LEEDS,DEPT MICROBIOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

[3] UNIV EDINBURGH,DEPT EAR NOSE & THROAT,EDINBURGH EH8 9YL,MIDLOTHIAN,SCOTLAND

来源：

CLINICAL OTOLARYNGOLOGY | 1990年 / 15卷 / 01期

关键词：

otorrhoea; topical antibiotics; topical antiseptics;

D O I：

10.1111/j.1365-2273.1990.tb00425.x

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The clinical efficacy was assessed of a topical antiseptic (aluminium acetate) and a topical antibiotic (gentamicin sulphate) for the initial treatment of otorrhoea. Evidence of resistant organisms developing to either treatments after 9 and 21 days was also examined. 139 affected ears were entered into the trial and of these, 102 (74%) completed the study. Improvement in the otorrhoea occurred in 68% of ears treated with gentamicin and 67% of ears treated with aluminium acetate, with no significant difference between the two treatments. No resistant organisms to aluminium acetate were encountered. Twelve gentamicin‐treated ears had gentamicin‐resistant organisms at presentation and one patient developed a gentamicin‐resistant Pseudomonas during treatment. We therefore recommend a topical antiseptic such as aluminium acetate rather than a topical antibiotic in the initial treatment of otorrhoea on the grounds of cost, avoidance of resistance and toxicity. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：7 / 10

页数：4

共 11 条

[1] CONTROLLED TRIAL OF MEDICAL-TREATMENT OF ACTIVE CHRONIC OTITIS-MEDIA [J].