SYNTHESIS AND ANTIVIRAL EVALUATION OF QUINAZOLINE, THIENO-[2,3-D]PYRIMIDINE, AND LUMAZINE ANALOGS OF 3'-FLUORO-3'-DEOXYTHYMIDINE (FLT)

被引：0

作者：

ELBARBARY, AA

ELBROLLOSY, NR

ABDELBARY, HM

PEDERSEN, EB

STEIN, P

NIELSEN, C

机构：

[1] ODENSE UNIV,DEPT CHEM,DK-5230 ODENSE M,DENMARK

[2] STATENS SERUM INST,DEPT VIROL,RETROVIRUS LAB,DK-2300 COPENHAGEN,DENMARK

来源：

LIEBIGS ANNALEN | 1995年 / 07期

关键词：

NUCLEOSIDES; HIV; 3'-FLUORONUCLEOSIDES; FLT ANALOGS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2,4(1H,3H)-Quinazolinediones 3a-c, lumazine (3d) and thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (8) were silylated and condensed with methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-beta-D-erythro-pentofuranoside (2) by using trimethylsilyl triflate as a catalyst to afford the corresponding cyclic nucleosides 4 and 9 and acyclic nucleosides 5 and 10. Removal of the protecting group from the glycon moiety was achieved in good yields by treatment with sodium methoxide in methanol at room temperature. The new FLT analogues were devoid of activity against HTV-1 and HSV-1.

引用

页码：1371 / 1375

页数：5