THE VASOCONSTRICTOR ACTION OF BIG ENDOTHELIN-1 IS PHOSPHORAMIDON-SENSITIVE IN RABBIT SAPHENOUS ARTERY, BUT NOT IN SAPHENOUS-VEIN

被引：12

作者：

AUGUET, M ^{[1
]}

DELAFLOTTE, S ^{[1
]}

CHABRIER, PE ^{[1
]}

BRAQUET, P ^{[1
]}

机构：

[1] INST HENRI BEAUFOUR,RES LABS,1 AVE TROP,F-91952 LES ULIS,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 224卷 / 01期

关键词：

ENDOTHELIN-1; ARTERY; VEIN;

D O I：

10.1016/0014-2999(92)94827-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of big endothelin-1 and endothelin-1 on vascular reactivity were compared in isolated rabbit saphenous artery and vein. The contractile potency of endothelin-1 was three times higher in the vein than in the artery. In contrast, big endothelin-I was two times more effective in the artery. Phosphoramidon (100 muM), a metalloproteinase inhibitor, antagonised the contractile action of big endothelin-I in the artery but not in the vein. These data suggest that the biosynthetic pathway leading to the formation of endothelin differs in arterial and venous vessels.

引用

页码：101 / 102

页数：2

共 5 条

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