MULTIMERIZATION OF ICP0, A HERPES-SIMPLEX VIRUS IMMEDIATE-EARLY PROTEIN

被引：29

作者：

CHEN, JX ^{[1
]}

PANAGIOTIDIS, C ^{[1
]}

SILVERSTEIN, S ^{[1
]}

机构：

[1] COLUMBIA UNIV,DEPT MICROBIOL,701 W 168TH ST,NEW YORK,NY 10032

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 09期

关键词：

D O I：

10.1128/JVI.66.9.5598-5602.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

ICP0, a herpes simplex virus immediate-early gene product, is a highly phosphorylated nuclear protein that is a potent activator of virus and host genes. Using biochemical and genetic assays employing plasmids encoding mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we provide evidence that the protein multimerizes. Some mutant forms of ICP0 were transdominant and interfered with activation of a target reporter gene or with complementation of an ICP0-minus virus.

引用

页码：5598 / 5602

页数：5

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