Guillain-Barre syndrome associated with dengue: Case report

Introduction: Dengue fever is an infectious disease, which is endemic in tropical and subtropical countries. To date, four serotypes have been well described, being the types 2 and 3 the mainly associated with neurological manifestations. Case report: A 50-year old female who four days previously was diagnosed with dengue fever presented ascendant muscular weakness up to flaccid quadriplegia, arreflexia and respiratory failure that merited mechanical ventilation. Conduction nerve studies evidenced mixed sensorimotor axonal and demielination polineuropathy compatible with Guillain-Barre syndrome. Serum antibodies IgM and IgG against Dengue virus and antibodies anti NS1 were also positive. In-hospital course was torpid with respiratory arrest and hypoxic brain injury, being discharge with severe sequels. Conclusions: The recent increase in the incidence and territorial spread of Dengue in Mexico, demands the early recognition and characterization of their central and peripheral manifestations.