EFFECTS OF ACUTE ETHANOL ADMINISTRATION ON REGIONAL SEROTONIN TURNOVER

被引：0

作者：

LAFUENTE, MA

MELGAR, MJ

VEIRA, JAR

ALDEGUNDE, MA

机构：

[1] UNIV SANTIAGO COMPOSTELA,DEPT PHYSIOL,E-27002 LUGO,SPAIN

[2] UNIV SANTIAGO COMPOSTELA,FAC BIOL,DEPT PHYSIOL,E-15706 SANTIAGO,SPAIN

来源：

VETERINARY AND HUMAN TOXICOLOGY | 1992年 / 34卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Numerous studies show the role of biogenic amines in the effects of ethanol. The present work analyzed the effect of an acute sedative-hypnotic dose of ethanol (4 g/kg) on the levels of tryptophan, serotonin (5-HT) and 5-hydroxyindol-acetic acid (5-HIAA), the serotonin synthesis rate and the 5-HIAA elimination rate in several regions of the brain. The 5-HT synthesis rate was not enhanced by ethanol administration, despite increases in brain tryptophan, 5-HT and 5-HIAA, which were primarily in the medulla-pons. The increased indole levels could be due to inhibition of 5-HIAA elimination from the brain.

引用

页码：504 / 507

页数：4

共 23 条

[1]

BACOPOULOS NG, 1978, J PHARMACOL EXP THER, V204, P1

[2]

Badawy A A, 1977, Adv Exp Med Biol, V85A, P559

[3] ROLE OF FREE SERUM TRYPTOPHAN IN BIPHASIC EFFECT OF ACUTE ETHANOL ADMINISTRATION ON CONCENTRATIONS OF RAT-BRAIN TRYPTOPHAN, 5-HYDROXYTRYPTAMINE AND 5-HYDROXYINDOL-3-YL-ACETIC ACID [J].