DECREASE IN MESSENGER-RNA LEVELS BUT NOT IN THE DENSITY OF D2 DOPAMINE-RECEPTORS IN RAT STRIATUM AFTER TRANSIENT FOREBRAIN ISCHEMIA

被引：17

作者：

BENFENATI, F ^{[1
]}

CIMINO, M ^{[1
]}

ZOLI, M ^{[1
]}

GRIMALDI, R ^{[1
]}

ZINI, I ^{[1
]}

AGNATI, LF ^{[1
]}

机构：

[1] UNIV URBINO,INST PHARMACOL & PHARMACOGNOSY,I-61029 URBINO,ITALY

来源：

NEUROSCIENCE LETTERS | 1991年 / 126卷 / 01期

关键词：

TRANSIENT FOREBRAIN ISCHEMIA; STRIATUM; DOPAMINE RECEPTOR; D2 RECEPTOR MESSENGER RNA; INSITU HYBRIDIZATION; AUTORADIOGRAPHY;

D O I：

10.1016/0304-3940(91)90357-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

D2 dopamine receptor mRNA was analyzed by in situ hybridization histochemistry in rat striatum 7 days after transient forebrain ischemia. A patchy disappearance of the D2 receptor mRNA was observed in the dorsolateral striatum. In the same area, a disappearance of D1 binding sites occurred in the absence of significant changes in D2 receptor density. These results suggest that, although D2 receptors seem to be apparently unaffected after forebrain ischemia, a long-lasting impairment of their neosynthesis may be present in striatal D2 dopaminoceptive neurons.

引用

页码：6 / 8

页数：3

共 50 条

[41] REGIONAL QUANTIFICATION OF D1, D2, AND D3 DOPAMINE-RECEPTOR MESSENGER-RNA IN RAT-BRAIN USING A RIBONUCLEASE PROTECTION ASSAY [J].

RICHTAND, NM ;

KELSOE, JR ;

SEGAL, DS ;

KUCZENSKI, R .

MOLECULAR BRAIN RESEARCH, 1995, 33 (01) :97-103

[42] EXPRESSION OF TRANSFORMING GROWTH-FACTOR-BETA-1 AND INTERLEUKIN-1-BETA MESSENGER-RNA IN RAT-BRAIN FOLLOWING TRANSIENT FOREBRAIN ISCHEMIA [J].

WIESSNER, C ;

GEHRMANN, J ;

LINDHOLM, D ;

TOPPER, R ;

KREUTZBERG, GW ;

HOSSMANN, KA .

ACTA NEUROPATHOLOGICA, 1993, 86 (05) :439-446

[43] OPPOSING ROLES FOR DOPAMINE D-2 AND D-3 RECEPTORS ON NEUROTENSIN MESSENGER-RNA EXPRESSION IN NUCLEUS-ACCUMBENS [J].

DIAZ, J ;

LEVESQUE, D ;

GRIFFON, N ;

LAMMERS, CH ;

MARTRES, MP ;

SOKOLOFF, P ;

SCHWARTZ, JC .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (08) :1384-1387

[44] D2 DOPAMINERGIC REGULATION OF STRIATAL PREPROENKEPHALIN MESSENGER-RNA LEVELS IS MEDIATED AT LEAST IN PART THROUGH CHOLINERGIC INTERNEURONS [J].

POLLACK, AE ;

WOOTEN, GF .

MOLECULAR BRAIN RESEARCH, 1992, 13 (1-2) :35-41

[45] Effects of repeated methamphetamine administration on dopamine D1 receptor, D2 receptor and adenylate cyclase type V mRNA levels in the rat striatum [J].

Shishido, T ;

Watanabe, Y ;

Suzuki, H ;

Kato, K ;

Niwa, SI ;

Hanoune, J ;

Matsuoka, I .

NEUROSCIENCE LETTERS, 1997, 222 (03) :175-178

[46] DOPAMINE-D(2) RECEPTOR MESSENGER-RNA IN THE PITUITARY DURING THE ESTROUS-CYCLE, PREGNANCY AND LACTATION IN THE RAT [J].

ZABAVNIK, J ;

WU, WX ;

EIDNE, KA ;

MCNEILLY, AS .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1993, 95 (1-2) :121-128

[47] ELECTROCONVULSIVE SHOCK INCREASES DOPAMINE D-1 AND D-2 RECEPTOR MESSENGER-RNA IN THE NUCLEUS-ACCUMBENS OF THE RAT [J].

SMITH, S ;

LINDEFORS, N ;

HURD, Y ;

SHARP, T .

PSYCHOPHARMACOLOGY, 1995, 120 (03) :333-340

[48] NEURONAL LOCALIZATION AND MODULATION OF THE D2 DOPAMINE RECEPTOR MESSENGER-RNA IN BRAIN OF NORMAL MICE AND MICE LESIONED WITH 6-HYDROXYDOPAMINE [J].

CHEN, JF ;

QIN, ZH ;

SZELE, F ;

BAI, G ;

WEISS, B .

NEUROPHARMACOLOGY, 1991, 30 (09) :927-+

[49] PRENATAL COCAINE EXPOSURE REVEALED MINIMAL POSTNATAL CHANGES IN RAT STRIATAL DOPAMINE D-2 RECEPTOR-SITES AND MESSENGER-RNA LEVELS IN THE OFFSPRING [J].

STADLIN, A ;

CHOI, HL ;

TSIM, KWK ;

TSANG, D .

MOLECULAR NEUROBIOLOGY, 1995, 11 (1-3) :67-76

[50] Amphetamine elevates phosphorylation of eukaryotic initiation factor 2α (eIF2α) in the rat forebrain via activating dopamine D1 and D2 receptors [J].

Xue, Bing ;

Fitzgerald, Cole A. ;

Jin, Dao-Zhong ;

Mao, Li-Min ;

Wang, John Q. .

BRAIN RESEARCH, 2016, 1646 :459-466

← 1 2 3 4 5 →