SYNTHESIS AND PRELIMINARY EVALUATION OF (+)-CBI-INDOLE2 - AN ENHANCED FUNCTIONAL ANALOG OF (+)-CC-1065

被引：59
作者：
BOGER, DL
ISHIZAKI, T
SAKYA, SM
MUNK, SA
KITOS, PA
JIN, Q
BESTERMAN, JM
机构：
[1] UNIV KANSAS,DEPT BIOCHEM,LAWRENCE,KS 66045
[2] GLAXO RES INST,DEPT CELL BIOL,RES TRIANGLE PK,NC 27709
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 02期
关键词：
D O I：
10.1016/S0960-894X(00)80243-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and comparative preliminary evaluation of (+)-CBI-indole2 (3) are detailed in efforts that further demonstrate a direct relationship between the chemical stability of the agents and their biological potency/DNA alkylation intensity.
引用
收藏
页码：115 / 120
页数：6
相关论文
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[1]   A DEMONSTRATION OF THE INTRINSIC IMPORTANCE OF STABILIZING HYDROPHOBIC BINDING AND NONCOVALENT VANDERWAALS CONTACTS DOMINANT IN THE NONCOVALENT CC-1065/B-DNA BINDING [J].
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[8]   TOTAL SYNTHESIS OF (+/-)-N-(PHENYLSULFONYL)-CI AND (+/-)-N-(TERT-BUTYLOXYCARBONYL)-CI, (+/-)-CI-CDPI1, AND (+/-)-CI-CDPI2 - CC-1065 FUNCTIONAL ANALOGS INCORPORATING THE PARENT 1,2,7,7A-TETRAHYDROCYCLOPROP[1,2-C]INDOL-4-ONE (CI) LEFT-HAND SUBUNIT [J].
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