AN ERYTHROID SPECIFIC ENHANCER UPSTREAM TO THE GENE ENCODING THE CELL-TYPE SPECIFIC TRANSCRIPTION FACTOR-GATA-1

被引：77
作者：
NICOLIS, S
BERTINI, C
RONCHI, A
CROTTA, S
LANFRANCO, L
MORONI, E
GIGLIONI, B
OTTOLENGHI, S
机构：
[1] UNIV MILAN, DIPARTIMENTO GENET & BIOL MICRORGANISMI, I-20122 MILAN, ITALY
[2] UNIV TURIN, DIPARTIMENTO GENET BIOL & CHIM MED, I-10124 TURIN, ITALY
[3] CNR, CTR STUD PATOL CELLULARE, I-20133 MILAN, ITALY
来源：
NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 19期
关键词：
D O I：
10.1093/nar/19.19.5285
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes. We have cloned the mouse and human GATA-1 genes. A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter. The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.
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页码：5285 / 5291
页数：7
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