Wnt signaling pathway in retinal vascularization

被引：38
作者：
Drenser, Kimberly A. [1 ]
机构：
[1] Associated Retinal Consultants, 3535 W Thirteen Mile Rd,Suite 344, Royal Oak, MI 48073 USA
来源：
EYE AND BRAIN | 2016年 / 8卷
关键词：
Wnt; norrin; angiogenesis; development; ROP; prematurity;
D O I：
10.2147/EB.S94452
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development. An increasing body of evidence supports the importance of Wnt-signaling, and specifically, norrin-mediated Wnt-signaling in retinal development and retinal maintenance. Gene mutations affecting the Wnt-signaling pathways result in a variety of inherited vitreoretinopathies. Additionally, there is growing evidence that prematurity and associated retinopathy are associated with alterations in the Wnt-signaling pathways. Further investigations may allow for improved diagnoses, management, and therapies in the future.
引用
收藏
页码：141 / 146
页数：6
相关论文
共 47 条
  • [1] Genetic susceptibility to retinopathy of prematurity
    Bizzarro, Matthew J.
    Hussain, Naveed
    Jonsson, Baldvin
    Feng, Rui
    Ment, Laura R.
    Gruen, Jeffrey R.
    Zhang, Heping
    Bhandari, Vineet
    [J]. PEDIATRICS, 2006, 118 (05) : 1858 - 1863
  • [2] Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis
    Black, GCM
    Perveen, R
    Bonshek, R
    Cahill, M
    Clayton-Smith, J
    Lloyd, IC
    McLeod, D
    [J]. HUMAN MOLECULAR GENETICS, 1999, 8 (11) : 2031 - 2035
  • [3] Cell signaling - Wnt moves beyond the Canon
    Bowerman, Bruce
    [J]. SCIENCE, 2008, 320 (5874) : 327 - 328
  • [4] The Different Functions of Norrin
    Braunger, Barbara M.
    Tamm, Ernst R.
    [J]. RETINAL DEGENERATIVE DISEASES, 2012, 723 : 679 - 683
  • [5] A mutation in the Norrie disease gene (NDP) associated with familial exudative vitreoretinopathy
    Chamney, S.
    McLoone, E.
    Willoughby, C. E.
    [J]. EYE, 2011, 25 (12) : 1658 - 1658
  • [6] Genetic diversity among Toxoplasma gondii strains from different hosts and geographical regions revealed by sequence analysis of GRA5 gene
    Chen, Jia
    Li, Zhong-Yuan
    Zhou, Dong-Hui
    Liu, Guo-Hua
    Zhu, Xing-Quan
    [J]. PARASITES & VECTORS, 2012, 5
  • [7] Wnt Signaling Mediates Pathological Vascular Growth in Proliferative Retinopathy
    Chen, Jing
    Stahl, Andreas
    Krah, Nathan M.
    Seaward, Molly R.
    Dennison, Roberta J.
    Sapieha, Przemyslaw
    Hua, Jing
    Hatton, Colman J.
    Juan, Aimee M.
    Aderman, Christopher M.
    Willett, Keirnan L.
    Guerin, Karen I.
    Mammoto, Akiko
    Campbell, Matthew
    Smith, Lois E. H.
    [J]. CIRCULATION, 2011, 124 (17) : 1871 - U230
  • [8] A MUTATION IN THE NORRIE DISEASE GENE (NDP) ASSOCIATED WITH X-LINKED FAMILIAL EXUDATIVE VITREORETINOPATHY
    CHEN, ZY
    BATTINELLI, EM
    FIELDER, A
    BUNDEY, S
    SIMS, K
    BREAKEFIELD, XO
    CRAIG, IW
    [J]. NATURE GENETICS, 1993, 5 (02) : 180 - 183
  • [9] A Mutation in the Signal Sequence of LRP5 in a Family With an Osteoporosis-Pseudoglioma Syndrome (OPPG)-Like Phenotype Indicates a Novel Disease Mechanism for Trinucleotide Repeats
    Chung, Boi-Dinh
    Kayserili, Huelya
    Ai, Minrong
    Freudenberg, Jan
    Uezmcue, Abdullah
    Uyguner, Oya
    Bartels, Cynthia F.
    Hoening, Stefan
    Ramirez, Alfredo
    Hanisch, Franz-Georg
    Nuernberg, Gudrun
    Nuernberg, Peter
    Warman, Matthew L.
    Wollnik, Bernd
    Kubisch, Christian
    Netzer, Christian
    [J]. HUMAN MUTATION, 2009, 30 (04) : 641 - 648
  • [10] Frizzled-4 Variations Associated with Retinopathy and Intrauterine Growth Retardation
    Dailey, Wendy A.
    Gryc, Wojciech
    Garg, Pooja G.
    Drenser, Kimberly A.
    [J]. OPHTHALMOLOGY, 2015, 122 (09) : 1917 - 1923
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