Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity

被引：17

作者：

Shapiro, Roman ^{[1
]}

Chin-Yee, Ian ^{[2
]}

Lam, Selay ^{[2
]}

机构：

[1] Western Univ, London Hlth Sci Ctr, Dept Med, London, ON, Canada

[2] Victoria Hosp, LHSC, Div Hematol, 800 Commissioners Rd East, London, ON N6A 5W9, Canada

来源：

CLINICAL CASE REPORTS | 2015年 / 3卷 / 11期

关键词：

Anti-Pr; cold autoimmune hemolytic anemia; eculizumab; rituximab;

D O I：

10.1002/ccr3.399

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Key Clinical Message Severe cold agglutinin disease with hemodynamic compromise requires rapid stabilization of the autoimmune hemolytic anemia as a bridge to the immunosuppressive effect of rituximab. Herein, we describe eculizumab treatment of severe complement-mediated hemolysis in a patient whose hemodynamic status deteriorated in spite of supportive blood transfusions and therapeutic plasma exchange.

引用

页码：942 / 944

页数：3

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