SYNTHESIS AND HYPOTENSIVE ACTIVITY OF N-ALKYL-N'-CYANO-N'-PYRIDYLGUANIDINES

被引:151
作者
PETERSEN, HJ [1 ]
NIELSEN, CK [1 ]
ARRIGONIMARTELLI, E [1 ]
机构
[1] LEO PHARMACEUT PROD,DEPT PHARMACOL,DK-2750 BALLERUP,DENMARK
关键词
D O I
10.1021/jm00206a011
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:773 / 781
页数:9
相关论文
共 13 条
[1]   COMMON EFFECT OF PHOSPHINES AND CARBON TETRACHLORIDE ON AMMONIA (DERIVATIVES) .4. NEW CARBODIIMIDE SYNTHESIS [J].
APPEL, R ;
KLEINSTU.R ;
ZIEHN, KD .
CHEMISCHE BERICHTE-RECUEIL, 1971, 104 (04) :1335-&
[2]   CIMETIDINE - NON-THIOUREA H2-RECEPTOR ANTAGONIST [J].
BRIMBLECOMBE, RW ;
DUNCAN, WAM ;
DURANT, GJ ;
EMMETT, JC ;
GANELLIN, CR ;
PARSONS, ME .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1975, 3 (02) :86-92
[3]   SYNTHETIC ANTIMALARIALS .28. AN ALTERNATIVE ROUTE TO N-1-ARYL-N-5-ALKYLDIGUANIDES [J].
CURD, FHS ;
HENDRY, JA ;
KENNY, TS ;
MURRAY, AG ;
ROSE, FL .
JOURNAL OF THE CHEMICAL SOCIETY, 1948, (OCT) :1630-1636
[4]   CYANOGUANIDINE-THIOUREA EQUIVALENCE IN DEVELOPMENT OF HISTAMINE H-2-RECEPTOR ANTAGONIST, CIMETIDINE [J].
DURANT, GJ ;
EMMETT, JC ;
GANELLIN, CR ;
MILES, PD ;
PARSONS, ME ;
PRAIN, HD ;
WHITE, GR .
JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (07) :901-906
[5]  
ELLENBOGEN L, 1974, ARCH INT PHARMACOD T, V207, P170
[6]   HYPOTENSIVE ACTIVITY OF SOME CYANOGUANIDINES [J].
GADEKAR, SM ;
NIBI, S ;
COHEN, E .
JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (04) :811-&
[7]  
LECHER HZ, 1949, Patent No. 2479498
[8]  
LITCHFIELD JT, 1949, J PHARMACOL EXP THER, V96, P99
[9]   ELIMINATION OF METHYL MERCAPTAN FROM N-SUBSTITUTED N'-CYANO-S-METHYLISOTHIOUREAS - EVIDENCE FOR N-CYANOCARBODIIMIDES [J].
MCCARTY, CG ;
PARKINSO.JE ;
WIELAND, DM .
JOURNAL OF ORGANIC CHEMISTRY, 1970, 35 (06) :2067-+
[10]  
NIELSEN CO, UNPUBLISHED