Malignant fibrous histiocytoma of the larynx is a very rare neoplasm. This article reports the case of a subglottic malignant fibrous histiocytoma in a 38-year-old male treated by wide excision and radiotherapy. A literature search reveals this to be the 22nd case reported. Clinicopathologic features are discussed. The treatment of choice is wide surgical excision with consideration of adjunctive chemotherapy. Radiation therapy is probably of little benefit.