SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF CONFORMATIONALLY RESTRICTED, ACETYLENIC RETINOID ANALOGS

被引：18

作者：

CHANDRARATNA, RAS ^{[1
]}

GILLETT, SJ ^{[1
]}

SONG, TK ^{[1
]}

ATTARD, J ^{[1
]}

VULIGONDA, S ^{[1
]}

GARST, ME ^{[1
]}

AREFIEG, T ^{[1
]}

GIL, DW ^{[1
]}

WHEELER, L ^{[1
]}

机构：

[1] ALLERGAN PHARMACEUT INC,RETINOID RES,DEPT BIOL,IRVINE,CA 92715

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0960-894X(95)00065-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The biological activity of retinoids an determined by their ability to activate one or more of six nuclear retinoid receptors (RARs and RXRs). We describe rigid, acetylenic retinoids that selectively transactivate through the RAR beta and RAR gamma subtypes and demonstrate their potent anti-proliferative activity in the skin.

引用

页码：523 / 527

页数：5

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