TREATMENT OF CANINE NASAL ASPERGILLOSIS WITH ENILCONAZOLE

被引：61

作者：

SHARP, NJH

SULLIVAN, M

HARVEY, CE

WEBB, T

机构：

[1] Department of Companion Animal and Special Species Medicine North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina

[2] University of Glasgow Veterinary School, Glasgow, Bearsden

[3] Veterinary Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

[4] Pfizer Central Research, Pfizer Ltd, Sandwich, Kent

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 1993年 / 7卷 / 01期

关键词：

D O I：

10.1111/j.1939-1676.1993.tb03167.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Twenty‐four dogs with nasal aspergillosis were treated with enilconazole (10 mg/kg bid for 7–14 days) administered topically through tubes surgically implanted into the nasal chambers. Aspergillosis was eliminated in 19 dogs over a median follow‐up period of 18 months. Another dog died, but at necropsy there was no evidence of causative fungus. Two of the four dogs that were not cured had infection of periorbital soft tissues. An additional seven dogs received 6 weeks ketoconazole (5 mg/kg bid PO) and enilconazole therapy topically. Six of these dogs were disease‐free over a median follow‐up period of 35 months. The seventh dog responded to repeated treatment with enilconazole. Twenty‐six of the 29 dogs (90%)without extranasal aspergillosis were cured. © 1993 American College of Veterinary Internal Medicine

引用

页码：40 / 43

页数：4

共 19 条

[1]

Harvey CE, OBrien JA, Felsburg PJ, Et al., Nasal penicilliosis in six dogs, J Am Vet Med Assoc, 178, pp. 1084-1087, (1981)

[2]

Sharp NJH., Canine nasal aspergillosis/peniciIliosis, Clinical Microbiology and Infectious Diseases of the Dog and Cat, pp. 714-718, (1990)

[3]

Harvey CE, OBrien JA., Nasal aspergillosis‐penicilliosis, Current Veterinary Therapy, VIII, pp. 236-241, (1983)

[4]

Sharp NJH, Burrell MH, Sullivan M., Et al., Canine nasal aspergillosis: serology and treatment with ketoconazole, J Small Anim Pract, 25, pp. 149-158, (1984)

[5]

Harvey CE., Nasal aspergillosis and penicilliosis in dogs: results of treatment with thiabendazole, J Am Vet Med Assoc, 184, pp. 48-50, (1984)

[6]

Sharp NJH, Sullivan M., Use of ketoconazole treatment of canine nasal aspergillosis, J Am Vet Med Assoc, 194, pp. 782-786, (1989)

[7]

Desplenter L., New possibilities in the treatment of dermatomycoses and ofAspergillus fumigatus, Proc 1st Eur Cong Vet Pharmacol Toxicol, Zeist, The Netherlands, pp. 266-274, (1979)

[8]

Sharp NJH, Sullivan M., Treatment of canine nasal aspergillosis with systemic ketoconazole and topical enilconazole, Vet Rec, 118, pp. 560-561, (1986)

[9]

Murray JL, Mahgoub ES., Further studies on the diagnosis of mycetoma by double diffusion in agar, Sabouraudia, 6, pp. 106-112, (1968)

[10]

Sharp NJH., Nasal aspergillosis, Current Veterinary Therapy, pp. 1106-1109, (1989)

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