GLYCOSYLATION OF ALPHA-1-ACID GLYCOPROTEIN IN RELATION TO DURATION OF DISEASE IN ACUTE AND CHRONIC INFECTION AND INFLAMMATION

被引：40

作者：

FASSBENDER, K

ZIMMERLI, W

KISSLING, R

SOBIESKA, M

AESCHLIMANN, A

KELLNER, M

MULLER, W

机构：

[1] UNIV HOSP BASEL,DEPT RHEUMATOL,CH-4031 BASEL,SWITZERLAND

[2] HOCHRHEININST RHEUMATISM RES,BAD SACKINGEN,GERMANY

[3] UNIV HOSP BASEL,DEPT RES & MED,CH-4031 BASEL,SWITZERLAND

[4] ORTHOPED UNIV HOSP BALGRIST,ZURICH,SWITZERLAND

[5] UNIV POSZNAN,SCH MED,POSZNAN,POLAND

来源：

CLINICA CHIMICA ACTA | 1991年 / 203卷 / 2-3期

关键词：

ALPHA-1-ACID GLYCOPROTEIN; GLYCOSYLATION; ACUTE BACTERIAL INFECTION; CHRONIC BACTERIAL INFECTION;

D O I：

10.1016/0009-8981(91)90304-U

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Microheterogeneity of acute phase proteins frequently differs in acute and chronic types of inflammation. However, it is unknown whether these changes depend on the duration of the inflammation in a given disease. We therefore investigated the microheterogeneity of alpha-1-acid glycoprotein (AGP) in sera from patients with acute and chronic bacterial infection in comparison to rheumatoid arthritis and ankylosing spondylitis. In acute bacterial infection Con A-reactivity of AGP was significantly elevated. By contrast, AGP in chronic bacterial infection showed the same glycosylation pattern as rheumatoid arthritis and ankylosing spondylitis being characterized by a decreased reactivity to Con A. Serial measurements in individual patients with bacterial infections showed a transition from the initially elevated to decreased reactivity to Con A as the disease became chronic.

引用

页码：315 / 328

页数：14

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