FAST SYSTEMATIC-APPROACH FOR THE DETERMINATION OF DRUGS IN BIOLOGICAL-FLUIDS BY FULLY AUTOMATED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ONLINE SOLID-PHASE EXTRACTION AND AUTOMATED CARTRIDGE EXCHANGE - APPLICATION TO CEBARACETAM IN HUMAN URINE

被引：10

作者：

CHOLLET, D

KUNSTNER, P

机构：

[1] Department of Toxicology and Pharmacokinetics, Zyma S.A., Nyon

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 577卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80255-O

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A fast stepwise systematic approach for the conversion of conventional reversed-phase high-performance liquid chromatographic (HPLC) assays involving liquid-liquid extraction of biological fluids into fully automated HPLC assays using solid-phase extraction and cartridge exchange is described. The suitability of this procedure is demonstrated for the determination of cebaracetam in human urine.

引用

页码：335 / 340

页数：6