2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN INHIBITION OF 17-BETA-ESTRADIOL-INDUCED INCREASES IN RAT UTERINE EPIDERMAL GROWTH-FACTOR RECEPTOR-BINDING ACTIVITY AND GENE-EXPRESSION

被引：86

作者：

ASTROFF, B ^{[1
]}

ROWLANDS, C ^{[1
]}

DICKERSON, R ^{[1
]}

SAFE, S ^{[1
]}

机构：

[1] TEXAS A&M UNIV SYST, DEPT VET PHYSIOL & PHARMACOL, COLLEGE STN, TX 77843 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1990年 / 72卷 / 03期

关键词：

2,3,7,8-Ttetrachlorodibenzo-p-dioxin; Epidermal growth factor receptor binding; Gene expression;

D O I：

10.1016/0303-7207(90)90149-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Treatment of immature female Sprague-Dawley rats with 17β-estradiol (5 μg/animal) resulted in an increase in uterine epidermal growth factor (EGF) receptor binding activity. Moreover, in a separate study it was also shown that 17β-estradiol increased steady-state levels of rat uterine EGF receptor mRNA as determined by Northern analysis. In contrast, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) caused a dose-response decrease in constitutive rat uterine EGF receptor binding activity and this was paralleled by a decrease in steady-state levels of uterine EGF receptor mRNA. Cotreatment of the animals with both TCDD (16 nmol/kg) and 17β-estradiol (5 μg/rat) gave results which showed that TCDD significantly inhibited the estrogen-induced increases in rat uterine EGF receptor binding activity and EGF receptor mRNA levels. These results further extend the range of antiestrogenic properties of TCDD and suggest that the inhibition of growth factor expression may play a role in the growth-inhibiting properties of TCDD in estrogen-responsive tissues or cells. © 1990.

引用

页码：247 / 252

页数：6

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