TURNOVER OF SERUM-PROTEINS IN RATS WITH ANALBUMINEMIA

被引：44

作者：

ESUMI, H ^{[1
]}

SATO, S ^{[1
]}

OKUI, M ^{[1
]}

SUGIMURA, T ^{[1
]}

NAGASE, S ^{[1
]}

机构：

[1] SASAKI INST,DEPT CHEM,CHIYODA KU,TOKYO,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 04期

关键词：

D O I：

10.1016/S0006-291X(79)80033-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the sera of a strain of rats with analbuminemia, the albumin concentration is less than a thousandth of that in normal rats. However, the total amount of serum proteins in the analbuminemic rats is almost the same as that in normal rats and no spots of additional proteins were observed on two dimensional gel electrophoresis. The half life of serum proteins as a whole in analbuminemic rats injected with [3H]-leucine was 3.0 days, being similar to that of 2.9 days in normal rats. The serum of analbuminemic rats gave 3 distinct peaks of protein and radioactivity (P1 to P3), while those of normal rats gave an additional peak of albumin (P4) on polyacrylamide gel electrophoresis. The half lives of P1, P2 and P3 were 4.2, 2.4 and 2.1 days, respectively in analbuminemic rats and 2.5, 1.7 and 2.3 days, respectively in normal rats. The concentrations of P1, P2 and P3 were 23.1, 19.9 and 20.9 mg/ml, respectively in analbuminemic rats and 4.4, 10.7 and 11.0 mg/ml, respectively in normal rats. The half lives of [3H]-labeled rat albumin injected into the blood of analbuminemic and normal rats were 8.0 and 3.5 days, respectively. © 1979 Academic Press, Inc. All rights of reproduction in any form reserved.

引用

页码：1191 / 1199

页数：9

共 11 条

[1] BENHOLD H, 1954, VERH DEUT GES INN ME, V60, P630
[2] BOMAN H, 1976, CLIN GENET, V9, P513
[3] ANALBUMINEMIA IN A NEONATE
CORMODE, EJ
LYSTER, DM
ISRAELS, S
[J]. JOURNAL OF PEDIATRICS, 1975, 86 (06) : 862 - 867
[4] CRANDALL L. A., 1934, American Journal of Digestive Diseases, V1, P126
[5] THE SIMULTANEOUS DETERMINATION OF RED CELL MASS AND PLASMA VOLUME IN MAN WITH RADIOACTIVE SODIUM CHROMATE AND CHROMIC CHLORIDE
GRAY, SJ
FRANK, H
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1953, 32 (10) : 1000 - 1004
[6] Gregersen M. I., 1944, JOUR LAB AND CLIN MED, V29, P1266
[7] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4
LAEMMLI, UK
[J]. NATURE, 1970, 227 (5259) : 680 - +
[8] Mancini G, 1965, Immunochemistry, V2, P235, DOI 10.1016/0019-2791(65)90004-2
[9] OFARRELL PH, 1974, J BIOL CHEM, V250, P4007
[10] ALBUMIN SYNTHESIS .1.
ROTHSCHILD, MA
SCHREIBER, SS
ORATZ, M
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1972, 286 (14) : 748 - +

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