NSAI ACTIVITY STUDY OF 4-PHENYL-2-THIOXO-BENZO[4,5]THIENO [2,3-D]PYRIMIDINE DERIVATIVES

被引：28

作者：

DARIAS, V ^{[1
]}

ABDALLAH, SS ^{[1
]}

TELLO, ML ^{[1
]}

DELGADO, LD ^{[1
]}

VEGA, S ^{[1
]}

机构：

[1] CSIC,INST QUIM MED,MADRID,SPAIN

来源：

ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 12期

关键词：

D O I：

10.1002/ardp.19943271205

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-phenyl-2-thioxo-benzo[4,5]thieno[2,3-d]pyrimidine derivatives endowed with anti-inflammatory and related pharmacological properties were submitted to a more extensive study to know their exact pharmacological profile and their possible side effects. The studied compounds possess a remarkable analgesic activity, devoid of central effects. They also show an interesting anti-inflammatory profile evidenced by their effectiveness in different experimental models of inflammation. In addition, these compounds exhibit none or very little activity on CNS, scarce toxicity and low gastrointestinal agressivity.

引用

页码：779 / 783

页数：5

共 20 条

[1] SOME ASPECTS OF PHARMACOLOGY OF IBUFENAC A NON-STEROIDAL ANTI-INFLAMMATORY AGENT [J].